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Extramedullary Involvement of the Ascending Colon in Relapsing Acute Lymphocytic Leukemia: A Case Report
Acute lymphoblastic leukemia (ALL) accounts for <1% of adult cancers. Extramedullary relapse of ALL has been primarily reported in pediatric patients or hematopoietic stem cell transplant recipients, and the gastrointestinal (GI) tract is a less frequently reported site of extramedullary relapse....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121693/ https://www.ncbi.nlm.nih.gov/pubmed/35602400 http://dx.doi.org/10.4103/sjmms.sjmms_543_21 |
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author | Ifthikar, Zainab Muthalib, Hamna Abdul Mohammed, Shamayel Alfraih, Feras A. Aljohany, Hesham A. Alsohaibani, Fahad I. |
author_facet | Ifthikar, Zainab Muthalib, Hamna Abdul Mohammed, Shamayel Alfraih, Feras A. Aljohany, Hesham A. Alsohaibani, Fahad I. |
author_sort | Ifthikar, Zainab |
collection | PubMed |
description | Acute lymphoblastic leukemia (ALL) accounts for <1% of adult cancers. Extramedullary relapse of ALL has been primarily reported in pediatric patients or hematopoietic stem cell transplant recipients, and the gastrointestinal (GI) tract is a less frequently reported site of extramedullary relapse. Here, we report a case of a 30-year-old male who was a known case of ALL with multiple relapses and allogenic stem cell transplantations. The patient presented with acute lower GI bleeding and was confirmed to have an extramedullary relapse of ALL in the ascending colon. As the patient already had early relapses after two hematopoietic stem cell transplants in the past, he was managed with palliative chemotherapy, consisting of vincristine, dexamethasone, and rituximab, following which the patient achieved complete remission. This case highlights the importance of recognizing uncommon presentations of ALL such as those involving the GI tract. |
format | Online Article Text |
id | pubmed-9121693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-91216932022-05-21 Extramedullary Involvement of the Ascending Colon in Relapsing Acute Lymphocytic Leukemia: A Case Report Ifthikar, Zainab Muthalib, Hamna Abdul Mohammed, Shamayel Alfraih, Feras A. Aljohany, Hesham A. Alsohaibani, Fahad I. Saudi J Med Med Sci Case Report Acute lymphoblastic leukemia (ALL) accounts for <1% of adult cancers. Extramedullary relapse of ALL has been primarily reported in pediatric patients or hematopoietic stem cell transplant recipients, and the gastrointestinal (GI) tract is a less frequently reported site of extramedullary relapse. Here, we report a case of a 30-year-old male who was a known case of ALL with multiple relapses and allogenic stem cell transplantations. The patient presented with acute lower GI bleeding and was confirmed to have an extramedullary relapse of ALL in the ascending colon. As the patient already had early relapses after two hematopoietic stem cell transplants in the past, he was managed with palliative chemotherapy, consisting of vincristine, dexamethasone, and rituximab, following which the patient achieved complete remission. This case highlights the importance of recognizing uncommon presentations of ALL such as those involving the GI tract. Wolters Kluwer - Medknow 2022 2022-04-21 /pmc/articles/PMC9121693/ /pubmed/35602400 http://dx.doi.org/10.4103/sjmms.sjmms_543_21 Text en Copyright: © 2022 Saudi Journal of Medicine & Medical Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Ifthikar, Zainab Muthalib, Hamna Abdul Mohammed, Shamayel Alfraih, Feras A. Aljohany, Hesham A. Alsohaibani, Fahad I. Extramedullary Involvement of the Ascending Colon in Relapsing Acute Lymphocytic Leukemia: A Case Report |
title | Extramedullary Involvement of the Ascending Colon in Relapsing Acute Lymphocytic Leukemia: A Case Report |
title_full | Extramedullary Involvement of the Ascending Colon in Relapsing Acute Lymphocytic Leukemia: A Case Report |
title_fullStr | Extramedullary Involvement of the Ascending Colon in Relapsing Acute Lymphocytic Leukemia: A Case Report |
title_full_unstemmed | Extramedullary Involvement of the Ascending Colon in Relapsing Acute Lymphocytic Leukemia: A Case Report |
title_short | Extramedullary Involvement of the Ascending Colon in Relapsing Acute Lymphocytic Leukemia: A Case Report |
title_sort | extramedullary involvement of the ascending colon in relapsing acute lymphocytic leukemia: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121693/ https://www.ncbi.nlm.nih.gov/pubmed/35602400 http://dx.doi.org/10.4103/sjmms.sjmms_543_21 |
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