Kaposi’s sarcoma herpesvirus activates the hypoxia response to usurp HIF2α-dependent translation initiation for replication and oncogenesis

Kaposi’s sarcoma herpesvirus (KSHV) is an angiogenesis-inducing oncovirus whose ability to usurp the oxygen-sensing machinery is central to its oncogenicity. By upregulating the hypoxia-inducible factors (HIFs), KSHV reprograms infected cells to a hypoxia-like state, triggering angiogenesis. Here we...

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Detalles Bibliográficos
Autores principales: Méndez-Solís, Omayra, Bendjennat, Mourad, Naipauer, Julian, Theodoridis, Phaedra R., Ho, J.J. David, Verdun, Ramiro E., Hare, Joshua M., Cesarman, Ethel, Lee, Stephen, Mesri, Enrique A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121799/
https://www.ncbi.nlm.nih.gov/pubmed/34965440
http://dx.doi.org/10.1016/j.celrep.2021.110144

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