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Predictive factors and outcomes of severe community acquired pneumonia in patients with respiratory failure

OBJECTIVES: To explore the risk factors, pathogens and outcomes of severe community-acquired pneumonia (SCAP) in patients with respiratory failure. METHODS: A prospective observational study was conducted at Northwest General Hospital & Research Centre, Peshawar, Pakistan from February 2016 to O...

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Autores principales: Ullah, Arslan Rahat, Masood, Aysha, Amin, Sumayya, Ali, Iftikhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121958/
https://www.ncbi.nlm.nih.gov/pubmed/35634599
http://dx.doi.org/10.12669/pjms.38.4.5312
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author Ullah, Arslan Rahat
Masood, Aysha
Amin, Sumayya
Ali, Iftikhar
author_facet Ullah, Arslan Rahat
Masood, Aysha
Amin, Sumayya
Ali, Iftikhar
author_sort Ullah, Arslan Rahat
collection PubMed
description OBJECTIVES: To explore the risk factors, pathogens and outcomes of severe community-acquired pneumonia (SCAP) in patients with respiratory failure. METHODS: A prospective observational study was conducted at Northwest General Hospital & Research Centre, Peshawar, Pakistan from February 2016 to October 2018. All patients with Community-acquired pneumonia (CAP) who fulfilled the inclusion criteria were recorded consecutively. Diagnosis of SCAP was made following the criteria established by the IDSA/ATS in the consensus guidelines on the management of CAP in adults published in 2007. In-hospital mortality was the main outcome. RESULTS: The final analysis comprised a total of 100 patients with SCAP. The mean age was 60.0±18.01 years, and 54.0% were female patients. Afghani patients represented 22.0% of the total patients. The most common comorbidity associated with SCAP was hypertension (42.0%). The most commonly isolated etiological agents were Acinetobacter baumannii, followed by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. In-hospital mortality was 45%. On multivariate analysis, factors associated with in-hospital mortality were age (OR 1.054; 95%Cl 1.01-1.10; p=0.021), presence of two or more complications (OR 4.51; 95%Cl 1.18-17.28; p=0.028), septic shock (OR 6.44; 95%Cl 1.55-26.803; p=0.010), length of mechanical ventilation (OR 1.17; 95%Cl 1.01-1.40; p=0.043), and paO(2) (OR 4.51; 95%Cl 1.18-17.28; p=0.004). CONCLUSION: A high mortality rate was observed in our study. Age, presence of two or more complications, septic shock, length of mechanical ventilation, and low paO(2) were identified to be independent predictors of mortality for patients with SCAP.
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spelling pubmed-91219582022-05-27 Predictive factors and outcomes of severe community acquired pneumonia in patients with respiratory failure Ullah, Arslan Rahat Masood, Aysha Amin, Sumayya Ali, Iftikhar Pak J Med Sci Original Article OBJECTIVES: To explore the risk factors, pathogens and outcomes of severe community-acquired pneumonia (SCAP) in patients with respiratory failure. METHODS: A prospective observational study was conducted at Northwest General Hospital & Research Centre, Peshawar, Pakistan from February 2016 to October 2018. All patients with Community-acquired pneumonia (CAP) who fulfilled the inclusion criteria were recorded consecutively. Diagnosis of SCAP was made following the criteria established by the IDSA/ATS in the consensus guidelines on the management of CAP in adults published in 2007. In-hospital mortality was the main outcome. RESULTS: The final analysis comprised a total of 100 patients with SCAP. The mean age was 60.0±18.01 years, and 54.0% were female patients. Afghani patients represented 22.0% of the total patients. The most common comorbidity associated with SCAP was hypertension (42.0%). The most commonly isolated etiological agents were Acinetobacter baumannii, followed by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. In-hospital mortality was 45%. On multivariate analysis, factors associated with in-hospital mortality were age (OR 1.054; 95%Cl 1.01-1.10; p=0.021), presence of two or more complications (OR 4.51; 95%Cl 1.18-17.28; p=0.028), septic shock (OR 6.44; 95%Cl 1.55-26.803; p=0.010), length of mechanical ventilation (OR 1.17; 95%Cl 1.01-1.40; p=0.043), and paO(2) (OR 4.51; 95%Cl 1.18-17.28; p=0.004). CONCLUSION: A high mortality rate was observed in our study. Age, presence of two or more complications, septic shock, length of mechanical ventilation, and low paO(2) were identified to be independent predictors of mortality for patients with SCAP. Professional Medical Publications 2022 /pmc/articles/PMC9121958/ /pubmed/35634599 http://dx.doi.org/10.12669/pjms.38.4.5312 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ullah, Arslan Rahat
Masood, Aysha
Amin, Sumayya
Ali, Iftikhar
Predictive factors and outcomes of severe community acquired pneumonia in patients with respiratory failure
title Predictive factors and outcomes of severe community acquired pneumonia in patients with respiratory failure
title_full Predictive factors and outcomes of severe community acquired pneumonia in patients with respiratory failure
title_fullStr Predictive factors and outcomes of severe community acquired pneumonia in patients with respiratory failure
title_full_unstemmed Predictive factors and outcomes of severe community acquired pneumonia in patients with respiratory failure
title_short Predictive factors and outcomes of severe community acquired pneumonia in patients with respiratory failure
title_sort predictive factors and outcomes of severe community acquired pneumonia in patients with respiratory failure
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121958/
https://www.ncbi.nlm.nih.gov/pubmed/35634599
http://dx.doi.org/10.12669/pjms.38.4.5312
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