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Successful Eradication of Hepatitis-C Virus with Sofosbuvir based Antiviral treatment results in improvement in quality of life in cirrhotic patients

OBJECTIVES: To document improvement in quality of life in patients with Hepatitis-C related cirrhosis after successful eradication of the virus. METHODS: In this observational cohort study conducted at Fatima Memorial Hospital from September 2015 to July 2017, patients with HCV were assessed for imp...

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Autores principales: Ali, Bushra, Raja, Ikram Ul Haq, Choudhry, Asad, Nawaz, Arif Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121959/
https://www.ncbi.nlm.nih.gov/pubmed/35634624
http://dx.doi.org/10.12669/pjms.38.4.4537
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author Ali, Bushra
Raja, Ikram Ul Haq
Choudhry, Asad
Nawaz, Arif Amir
author_facet Ali, Bushra
Raja, Ikram Ul Haq
Choudhry, Asad
Nawaz, Arif Amir
author_sort Ali, Bushra
collection PubMed
description OBJECTIVES: To document improvement in quality of life in patients with Hepatitis-C related cirrhosis after successful eradication of the virus. METHODS: In this observational cohort study conducted at Fatima Memorial Hospital from September 2015 to July 2017, patients with HCV were assessed for improvement in quality of life by using FACIT-F questionnaire. We compared the Quality of life (QOL) score before the start of treatment with DAAs and after achieving SVR12 in various aspects of quality of life including physical, emotional, functional and social well-being. RESULTS: A total of 71 patients, 52 (73%) were CTP class A, 18 (25%) in B and one (1.4%) in C. The mean score of QOL before AVT was 23.93±7.04 and after achieving SVR it was 36.83±6.36 (P-value <0.001). In the subcategories, score of functional wellbeing, physical well-being and social wellbeing were significantly improved except emotional wellbeing scores. All scores improved across the spectrum of patients in the CTP class A and B. There was only one patient in the CTP-C class. CONCLUSION: Chronic HCV infection complicated by cirrhosis causes a significant decline in quality of life. There was a marked improvement in the functional, social and physical health of the patients after eradication of Hepatitis-C with anti-viral therapy except emotional health of the individuals.
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spelling pubmed-91219592022-05-27 Successful Eradication of Hepatitis-C Virus with Sofosbuvir based Antiviral treatment results in improvement in quality of life in cirrhotic patients Ali, Bushra Raja, Ikram Ul Haq Choudhry, Asad Nawaz, Arif Amir Pak J Med Sci Original Article OBJECTIVES: To document improvement in quality of life in patients with Hepatitis-C related cirrhosis after successful eradication of the virus. METHODS: In this observational cohort study conducted at Fatima Memorial Hospital from September 2015 to July 2017, patients with HCV were assessed for improvement in quality of life by using FACIT-F questionnaire. We compared the Quality of life (QOL) score before the start of treatment with DAAs and after achieving SVR12 in various aspects of quality of life including physical, emotional, functional and social well-being. RESULTS: A total of 71 patients, 52 (73%) were CTP class A, 18 (25%) in B and one (1.4%) in C. The mean score of QOL before AVT was 23.93±7.04 and after achieving SVR it was 36.83±6.36 (P-value <0.001). In the subcategories, score of functional wellbeing, physical well-being and social wellbeing were significantly improved except emotional wellbeing scores. All scores improved across the spectrum of patients in the CTP class A and B. There was only one patient in the CTP-C class. CONCLUSION: Chronic HCV infection complicated by cirrhosis causes a significant decline in quality of life. There was a marked improvement in the functional, social and physical health of the patients after eradication of Hepatitis-C with anti-viral therapy except emotional health of the individuals. Professional Medical Publications 2022 /pmc/articles/PMC9121959/ /pubmed/35634624 http://dx.doi.org/10.12669/pjms.38.4.4537 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ali, Bushra
Raja, Ikram Ul Haq
Choudhry, Asad
Nawaz, Arif Amir
Successful Eradication of Hepatitis-C Virus with Sofosbuvir based Antiviral treatment results in improvement in quality of life in cirrhotic patients
title Successful Eradication of Hepatitis-C Virus with Sofosbuvir based Antiviral treatment results in improvement in quality of life in cirrhotic patients
title_full Successful Eradication of Hepatitis-C Virus with Sofosbuvir based Antiviral treatment results in improvement in quality of life in cirrhotic patients
title_fullStr Successful Eradication of Hepatitis-C Virus with Sofosbuvir based Antiviral treatment results in improvement in quality of life in cirrhotic patients
title_full_unstemmed Successful Eradication of Hepatitis-C Virus with Sofosbuvir based Antiviral treatment results in improvement in quality of life in cirrhotic patients
title_short Successful Eradication of Hepatitis-C Virus with Sofosbuvir based Antiviral treatment results in improvement in quality of life in cirrhotic patients
title_sort successful eradication of hepatitis-c virus with sofosbuvir based antiviral treatment results in improvement in quality of life in cirrhotic patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121959/
https://www.ncbi.nlm.nih.gov/pubmed/35634624
http://dx.doi.org/10.12669/pjms.38.4.4537
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