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Frequency and Risk Factors for Acute Kidney Injury in patients with COVID-19
OBJECTIVE: To determine the frequency of Acute Kidney Injury (AKI) and its underlying risk factors in patients with Coronavirus Disease (COVID-19). METHODS: This retrospective study was conducted by reviewing the medical records of patients admitted in Covid-19 Intensive Care Unit (ICU) of Farooq Ho...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121968/ https://www.ncbi.nlm.nih.gov/pubmed/35634634 http://dx.doi.org/10.12669/pjms.38.4.4980 |
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author | Anees, Muhammad Farooq, Omair Raza, Muhammad Mumtaz, Asim |
author_facet | Anees, Muhammad Farooq, Omair Raza, Muhammad Mumtaz, Asim |
author_sort | Anees, Muhammad |
collection | PubMed |
description | OBJECTIVE: To determine the frequency of Acute Kidney Injury (AKI) and its underlying risk factors in patients with Coronavirus Disease (COVID-19). METHODS: This retrospective study was conducted by reviewing the medical records of patients admitted in Covid-19 Intensive Care Unit (ICU) of Farooq Hospital, West Wood Branch, Lahore during the period from 1(st) April, 2020 to 30(th) June, 2020. COVID-19 was diagnosed on basis of Real Time Polymerase Chain Reaction (RT-PCR) through nasal swab. Demographic, clinical and laboratory data were collected at the time of admission in the hospital. AKI was diagnosed on basis of ≥ 0.3 mg/dl increase in serum Creatinine (sCr) from baseline during the hospital stay. The outcome of study was AKI. RESULTS: One hundred and seventy-six patients who fulfilled the inclusion criteria were recruited of which most were males (78.4%). The mean age was 51.26 ± 15.20 years and the frequency of AKI was 51.1%. The risk factors for AKI were increasing age (OR=2.10, p=0.017); presence of COVID-19 symptoms (OR=6.62, p=0.004); prolonged hospital stay (OR=2.26, p=0.011); Diabetes Mellitus (OR=1.81, p=0.057); hypoxemia (OR=5.98, p=0.000); leukocytosis (OR=2.91, p=0.002); lymphopenia (OR=5.77, p=0.000); hypoalbuminemia (OR=4.94, p=0.000); elevated C-reactive protein (CRP) (OR=6.20, p=0.000) and raised D-diamers (OR=3.16, p=0.000). CONCLUSIONS: AKI was present in half of the COVID-19 patients. The most significant risk factors for AKI were increasing age, prolonged hospital stay, hypoxemia, hypoalbuminemia, DM and raised inflammatory markers. |
format | Online Article Text |
id | pubmed-9121968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Professional Medical Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-91219682022-05-27 Frequency and Risk Factors for Acute Kidney Injury in patients with COVID-19 Anees, Muhammad Farooq, Omair Raza, Muhammad Mumtaz, Asim Pak J Med Sci Original Article OBJECTIVE: To determine the frequency of Acute Kidney Injury (AKI) and its underlying risk factors in patients with Coronavirus Disease (COVID-19). METHODS: This retrospective study was conducted by reviewing the medical records of patients admitted in Covid-19 Intensive Care Unit (ICU) of Farooq Hospital, West Wood Branch, Lahore during the period from 1(st) April, 2020 to 30(th) June, 2020. COVID-19 was diagnosed on basis of Real Time Polymerase Chain Reaction (RT-PCR) through nasal swab. Demographic, clinical and laboratory data were collected at the time of admission in the hospital. AKI was diagnosed on basis of ≥ 0.3 mg/dl increase in serum Creatinine (sCr) from baseline during the hospital stay. The outcome of study was AKI. RESULTS: One hundred and seventy-six patients who fulfilled the inclusion criteria were recruited of which most were males (78.4%). The mean age was 51.26 ± 15.20 years and the frequency of AKI was 51.1%. The risk factors for AKI were increasing age (OR=2.10, p=0.017); presence of COVID-19 symptoms (OR=6.62, p=0.004); prolonged hospital stay (OR=2.26, p=0.011); Diabetes Mellitus (OR=1.81, p=0.057); hypoxemia (OR=5.98, p=0.000); leukocytosis (OR=2.91, p=0.002); lymphopenia (OR=5.77, p=0.000); hypoalbuminemia (OR=4.94, p=0.000); elevated C-reactive protein (CRP) (OR=6.20, p=0.000) and raised D-diamers (OR=3.16, p=0.000). CONCLUSIONS: AKI was present in half of the COVID-19 patients. The most significant risk factors for AKI were increasing age, prolonged hospital stay, hypoxemia, hypoalbuminemia, DM and raised inflammatory markers. Professional Medical Publications 2022 /pmc/articles/PMC9121968/ /pubmed/35634634 http://dx.doi.org/10.12669/pjms.38.4.4980 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Anees, Muhammad Farooq, Omair Raza, Muhammad Mumtaz, Asim Frequency and Risk Factors for Acute Kidney Injury in patients with COVID-19 |
title | Frequency and Risk Factors for Acute Kidney Injury in patients with COVID-19 |
title_full | Frequency and Risk Factors for Acute Kidney Injury in patients with COVID-19 |
title_fullStr | Frequency and Risk Factors for Acute Kidney Injury in patients with COVID-19 |
title_full_unstemmed | Frequency and Risk Factors for Acute Kidney Injury in patients with COVID-19 |
title_short | Frequency and Risk Factors for Acute Kidney Injury in patients with COVID-19 |
title_sort | frequency and risk factors for acute kidney injury in patients with covid-19 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121968/ https://www.ncbi.nlm.nih.gov/pubmed/35634634 http://dx.doi.org/10.12669/pjms.38.4.4980 |
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