Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus

BACKGROUND: Hemichorea-hemiballismus is a rare hyperkinetic movement disorder. CASE REPORT: A 90-year-old male developed left hemichorea-hemiballismus after his second dose of the Pfizer-BioNTech COVID-19 vaccine. A wide range of investigations including magnetic resonance imaging did not reveal an...

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Detalles Bibliográficos
Autores principales: Batot, Cédric, Chea, Maryane, Zeidan, Sinead, Mongin, Marie, Pop, Gabriel, Mazoyer, Julie, Degos, Bertrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ubiquity Press 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122005/
https://www.ncbi.nlm.nih.gov/pubmed/35646423
http://dx.doi.org/10.5334/tohm.688
Descripción
Sumario:BACKGROUND: Hemichorea-hemiballismus is a rare hyperkinetic movement disorder. CASE REPORT: A 90-year-old male developed left hemichorea-hemiballismus after his second dose of the Pfizer-BioNTech COVID-19 vaccine. A wide range of investigations including magnetic resonance imaging did not reveal an alternative cause. [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) showed increases in right putamen fixation compared to the left side. The patient showed significant improvement after five days of intravenous corticosteroids, with a normal FDG-PET. DISCUSSION: This hemichorea-hemiballismus case shows dynamic restoration of putamen metabolism mirroring clinical evolution after administration of corticosteroids, suggesting an autoimmune COVID-19 vaccine-induced reaction.

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