Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus

BACKGROUND: Hemichorea-hemiballismus is a rare hyperkinetic movement disorder. CASE REPORT: A 90-year-old male developed left hemichorea-hemiballismus after his second dose of the Pfizer-BioNTech COVID-19 vaccine. A wide range of investigations including magnetic resonance imaging did not reveal an...

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Autores principales: Batot, Cédric, Chea, Maryane, Zeidan, Sinead, Mongin, Marie, Pop, Gabriel, Mazoyer, Julie, Degos, Bertrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ubiquity Press 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122005/
https://www.ncbi.nlm.nih.gov/pubmed/35646423
http://dx.doi.org/10.5334/tohm.688
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author Batot, Cédric
Chea, Maryane
Zeidan, Sinead
Mongin, Marie
Pop, Gabriel
Mazoyer, Julie
Degos, Bertrand
author_facet Batot, Cédric
Chea, Maryane
Zeidan, Sinead
Mongin, Marie
Pop, Gabriel
Mazoyer, Julie
Degos, Bertrand
author_sort Batot, Cédric
collection PubMed
description BACKGROUND: Hemichorea-hemiballismus is a rare hyperkinetic movement disorder. CASE REPORT: A 90-year-old male developed left hemichorea-hemiballismus after his second dose of the Pfizer-BioNTech COVID-19 vaccine. A wide range of investigations including magnetic resonance imaging did not reveal an alternative cause. [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) showed increases in right putamen fixation compared to the left side. The patient showed significant improvement after five days of intravenous corticosteroids, with a normal FDG-PET. DISCUSSION: This hemichorea-hemiballismus case shows dynamic restoration of putamen metabolism mirroring clinical evolution after administration of corticosteroids, suggesting an autoimmune COVID-19 vaccine-induced reaction.
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spelling pubmed-91220052022-05-27 Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus Batot, Cédric Chea, Maryane Zeidan, Sinead Mongin, Marie Pop, Gabriel Mazoyer, Julie Degos, Bertrand Tremor Other Hyperkinet Mov (N Y) Case Report BACKGROUND: Hemichorea-hemiballismus is a rare hyperkinetic movement disorder. CASE REPORT: A 90-year-old male developed left hemichorea-hemiballismus after his second dose of the Pfizer-BioNTech COVID-19 vaccine. A wide range of investigations including magnetic resonance imaging did not reveal an alternative cause. [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) showed increases in right putamen fixation compared to the left side. The patient showed significant improvement after five days of intravenous corticosteroids, with a normal FDG-PET. DISCUSSION: This hemichorea-hemiballismus case shows dynamic restoration of putamen metabolism mirroring clinical evolution after administration of corticosteroids, suggesting an autoimmune COVID-19 vaccine-induced reaction. Ubiquity Press 2022-05-18 /pmc/articles/PMC9122005/ /pubmed/35646423 http://dx.doi.org/10.5334/tohm.688 Text en Copyright: © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Batot, Cédric
Chea, Maryane
Zeidan, Sinead
Mongin, Marie
Pop, Gabriel
Mazoyer, Julie
Degos, Bertrand
Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus
title Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus
title_full Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus
title_fullStr Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus
title_full_unstemmed Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus
title_short Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus
title_sort clinical and radiological follow-up of a pfizer-biontech covid-19 vaccine-induced hemichorea-hemiballismus
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122005/
https://www.ncbi.nlm.nih.gov/pubmed/35646423
http://dx.doi.org/10.5334/tohm.688
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