AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs

AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity which contributes to learning and memory formation, relies on the accumulation of AMPARs at the postsynapse. This pheno...

Descripción completa

Detalles Bibliográficos
Autores principales: Díaz-Alonso, Javier, Nicoll, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122021/
https://www.ncbi.nlm.nih.gov/pubmed/34271016
http://dx.doi.org/10.1016/j.neuropharm.2021.108710
_version_ 1784711265598308352
author Díaz-Alonso, Javier
Nicoll, Roger A.
author_facet Díaz-Alonso, Javier
Nicoll, Roger A.
author_sort Díaz-Alonso, Javier
collection PubMed
description AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity which contributes to learning and memory formation, relies on the accumulation of AMPARs at the postsynapse. This phenomenon requires the coordinated recruitment of different elements in the AMPAR complex. Based on recent research reviewed herein, we propose an updated AMPAR trafficking and LTP model which incorporates both extracellular as well as intracellular mechanisms.
format Online
Article
Text
id pubmed-9122021
institution National Center for Biotechnology Information
language English
publishDate 2021
record_format MEDLINE/PubMed
spelling pubmed-91220212022-05-20 AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs Díaz-Alonso, Javier Nicoll, Roger A. Neuropharmacology Article AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity which contributes to learning and memory formation, relies on the accumulation of AMPARs at the postsynapse. This phenomenon requires the coordinated recruitment of different elements in the AMPAR complex. Based on recent research reviewed herein, we propose an updated AMPAR trafficking and LTP model which incorporates both extracellular as well as intracellular mechanisms. 2021-10-01 2021-07-13 /pmc/articles/PMC9122021/ /pubmed/34271016 http://dx.doi.org/10.1016/j.neuropharm.2021.108710 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Díaz-Alonso, Javier
Nicoll, Roger A.
AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
title AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
title_full AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
title_fullStr AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
title_full_unstemmed AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
title_short AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
title_sort ampa receptor trafficking and ltp: carboxy-termini, amino-termini and tarps
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122021/
https://www.ncbi.nlm.nih.gov/pubmed/34271016
http://dx.doi.org/10.1016/j.neuropharm.2021.108710
work_keys_str_mv AT diazalonsojavier ampareceptortraffickingandltpcarboxyterminiaminoterminiandtarps
AT nicollrogera ampareceptortraffickingandltpcarboxyterminiaminoterminiandtarps

Ejemplares similares