Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium

BACKGROUND: Both elevated and low resting heart rates are associated with atrial fibrillation (AF), suggesting a U-shaped relationship. However, evidence for a U-shaped causal association between genetically-determined resting heart rate and incident AF is limited. We investigated potential directio...

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Detalles Bibliográficos
Autores principales: Siland, J. E., Geelhoed, B., Roselli, C., Wang, B., Lin, H. J., Weiss, S., Trompet, S., van den Berg, M. E., Soliman, E. Z., Chen, L. Y., Ford, I., Jukema, J. W., Macfarlane, P. W., Kornej, J., Lin, H., Lunetta, K. L., Kavousi, M., Kors, J. A., Ikram, M. A., Guo, X., Yao, J., Dörr, M., Felix, S. B., Völker, U., Sotoodehnia, N., Arking, D. E., Stricker, B. H., Heckbert, S. R., Lubitz, S. A., Benjamin, E. J., Alonso, A., Ellinor, P. T., van der Harst, P., Rienstra, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122202/
https://www.ncbi.nlm.nih.gov/pubmed/35594314
http://dx.doi.org/10.1371/journal.pone.0268768

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