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Effects of arsenic on the topology and solubility of promyelocytic leukemia (PML)-nuclear bodies
Promyelocytic leukemia (PML) proteins are involved in the pathogenesis of acute promyelocytic leukemia (APL). Trivalent arsenic (As(3+)) is known to cure APL by binding to cysteine residues of PML and enhance the degradation of PML-retinoic acid receptor α (RARα), a t(15;17) gene translocation produ...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122205/ https://www.ncbi.nlm.nih.gov/pubmed/35594310 http://dx.doi.org/10.1371/journal.pone.0268835 |