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Effects of arsenic on the topology and solubility of promyelocytic leukemia (PML)-nuclear bodies

Promyelocytic leukemia (PML) proteins are involved in the pathogenesis of acute promyelocytic leukemia (APL). Trivalent arsenic (As(3+)) is known to cure APL by binding to cysteine residues of PML and enhance the degradation of PML-retinoic acid receptor α (RARα), a t(15;17) gene translocation produ...

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Detalles Bibliográficos
Autores principales:	Hirano, Seishiro, Udagawa, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122205/ https://www.ncbi.nlm.nih.gov/pubmed/35594310 http://dx.doi.org/10.1371/journal.pone.0268835

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