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Superinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks
Viral superinfection occurs when multiple viral particles subsequently infect the same host. In nature, several viral species are found to have evolved diverse mechanisms to prevent superinfection (superinfection exclusion) but how this strategic choice impacts the fate of mutations in the viral pop...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122224/ https://www.ncbi.nlm.nih.gov/pubmed/35536864 http://dx.doi.org/10.1371/journal.pcbi.1010125 |
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author | Hunter, Michael Fusco, Diana |
author_facet | Hunter, Michael Fusco, Diana |
author_sort | Hunter, Michael |
collection | PubMed |
description | Viral superinfection occurs when multiple viral particles subsequently infect the same host. In nature, several viral species are found to have evolved diverse mechanisms to prevent superinfection (superinfection exclusion) but how this strategic choice impacts the fate of mutations in the viral population remains unclear. Using stochastic simulations, we find that genetic drift is suppressed when superinfection occurs, thus facilitating the fixation of beneficial mutations and the removal of deleterious ones. Interestingly, we also find that the competitive (dis)advantage associated with variations in life history parameters is not necessarily captured by the viral growth rate for either infection strategy. Putting these together, we then show that a mutant with superinfection exclusion will easily overtake a superinfecting population even if the latter has a much higher growth rate. Our findings suggest that while superinfection exclusion can negatively impact the long-term adaptation of a viral population, in the short-term it is ultimately a winning strategy. |
format | Online Article Text |
id | pubmed-9122224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-91222242022-05-21 Superinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks Hunter, Michael Fusco, Diana PLoS Comput Biol Research Article Viral superinfection occurs when multiple viral particles subsequently infect the same host. In nature, several viral species are found to have evolved diverse mechanisms to prevent superinfection (superinfection exclusion) but how this strategic choice impacts the fate of mutations in the viral population remains unclear. Using stochastic simulations, we find that genetic drift is suppressed when superinfection occurs, thus facilitating the fixation of beneficial mutations and the removal of deleterious ones. Interestingly, we also find that the competitive (dis)advantage associated with variations in life history parameters is not necessarily captured by the viral growth rate for either infection strategy. Putting these together, we then show that a mutant with superinfection exclusion will easily overtake a superinfecting population even if the latter has a much higher growth rate. Our findings suggest that while superinfection exclusion can negatively impact the long-term adaptation of a viral population, in the short-term it is ultimately a winning strategy. Public Library of Science 2022-05-10 /pmc/articles/PMC9122224/ /pubmed/35536864 http://dx.doi.org/10.1371/journal.pcbi.1010125 Text en © 2022 Hunter, Fusco https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Hunter, Michael Fusco, Diana Superinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks |
title | Superinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks |
title_full | Superinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks |
title_fullStr | Superinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks |
title_full_unstemmed | Superinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks |
title_short | Superinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks |
title_sort | superinfection exclusion: a viral strategy with short-term benefits and long-term drawbacks |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122224/ https://www.ncbi.nlm.nih.gov/pubmed/35536864 http://dx.doi.org/10.1371/journal.pcbi.1010125 |
work_keys_str_mv | AT huntermichael superinfectionexclusionaviralstrategywithshorttermbenefitsandlongtermdrawbacks AT fuscodiana superinfectionexclusionaviralstrategywithshorttermbenefitsandlongtermdrawbacks |