Co-treatment with Vactosertib, a Novel, Orally Bioavailable Activin Receptor-like Kinase 5 Inhibitor, Suppresses Radiotherapy-induced Epithelial-to-mesenchymal Transition, Cancer Cell Stemness, and Lung Metastasis of Breast Cancer

BACKGROUND: Acquired metastasis and invasion of cancer cells during radiotherapy are in part due to induction of epithelial-to-mesenchymal transition (EMT) and cancer stem cell (CSC) properties, which are mediated by TGF-β signaling. Here we evaluated the anti-metastatic therapeutic potential of vac...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Jiwon, Park, Jiyoung, Cho, Ilyoung, Sheen, Yhunyhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122287/
https://www.ncbi.nlm.nih.gov/pubmed/35390248
http://dx.doi.org/10.2478/raon-2022-0012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122287/
https://www.ncbi.nlm.nih.gov/pubmed/35390248
http://dx.doi.org/10.2478/raon-2022-0012

Ejemplares similares