Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts

Phosphorylation and acetylation of sarcomeric proteins are important for fine-tuning myocardial contractility. Here, we used bottom-up proteomics and label-free quantification to identify novel post-translational modifications (PTMs) on β-myosin heavy chain (β-MHC) in normal and failing human heart...

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Detalles Bibliográficos
Autores principales: Landim-Vieira, Maicon, Childers, Matthew C, Wacker, Amanda L, Garcia, Michelle Rodriquez, He, Huan, Singh, Rakesh, Brundage, Elizabeth A, Johnston, Jamie R, Whitson, Bryan A, Chase, P Bryant, Janssen, Paul ML, Regnier, Michael, Biesiadecki, Brandon J, Pinto, J Renato, Parvatiyar, Michelle S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122498/
https://www.ncbi.nlm.nih.gov/pubmed/35502901
http://dx.doi.org/10.7554/eLife.74919

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