P-TEFb is degraded by Siah1/2 in quiescent cells

P-TEFb, composed of CycT1 and CDK9, regulates the elongation of transcription by RNA polymerase II. In proliferating cells, it is regulated by 7SK snRNA in the 7SK snRNP complex. In resting cells, P-TEFb is absent, because CycT1 is dephosphorylated, released from CDK9 and rapidly degraded. In this s...

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Detalles Bibliográficos
Autores principales: Huang, Fang, Feng, Yongmei, Peterlin, B Matija, Fujinaga, Koh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122529/
https://www.ncbi.nlm.nih.gov/pubmed/35524561
http://dx.doi.org/10.1093/nar/gkac291

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