Definition of germ layer cell lineage alternative splicing programs reveals a critical role for Quaking in specifying cardiac cell fate

Alternative splicing is critical for development; however, its role in the specification of the three embryonic germ layers is poorly understood. By performing RNA-Seq on human embryonic stem cells (hESCs) and derived definitive endoderm, cardiac mesoderm, and ectoderm cell lineages, we detect disti...

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Detalles Bibliográficos
Autores principales: Fagg, W Samuel, Liu, Naiyou, Braunschweig, Ulrich, Pereira de Castro, Karen Larissa, Chen, Xiaoting, Ditmars, Frederick S, Widen, Steven G, Donohue, John Paul, Modis, Katalin, Russell, William K, Fair, Jeffrey H, Weirauch, Matthew T, Blencowe, Benjamin J, Garcia-Blanco, Mariano A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122611/
https://www.ncbi.nlm.nih.gov/pubmed/35544276
http://dx.doi.org/10.1093/nar/gkac327

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