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The wave of the SARS-CoV-2 Omicron variant resulted in a rapid spike and decline as highlighted by municipal wastewater surveillance
This paper highlights the extraordinarily rapid spread of SARS-CoV-2 loads in wastewater that during the Omicron wave in December 2021–February 2022, compared with the profiles acquired in 2020–21 with 410 samples from two wastewater treatment plants (Trento+suburbs, 132,500 inhabitants). Monitoring...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122782/ https://www.ncbi.nlm.nih.gov/pubmed/35615435 http://dx.doi.org/10.1016/j.eti.2022.102667 |
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author | Cutrupi, Francesca Cadonna, Maria Manara, Serena Postinghel, Mattia La Rosa, Giuseppina Suffredini, Elisabetta Foladori, Paola |
author_facet | Cutrupi, Francesca Cadonna, Maria Manara, Serena Postinghel, Mattia La Rosa, Giuseppina Suffredini, Elisabetta Foladori, Paola |
author_sort | Cutrupi, Francesca |
collection | PubMed |
description | This paper highlights the extraordinarily rapid spread of SARS-CoV-2 loads in wastewater that during the Omicron wave in December 2021–February 2022, compared with the profiles acquired in 2020–21 with 410 samples from two wastewater treatment plants (Trento+suburbs, 132,500 inhabitants). Monitoring of SARS-CoV-2 in wastewater focused on: (i) 3 samplings/week and analysis, (ii) normalization to calculate genomic units (GU) inh(−1) d(−1); (iii) calculation of a 7-day moving average to smooth daily fluctuations; (iv) comparison with the ‘current active cases’/100,000 inh progressively affected by the mass vaccination. The time profiles of SARS-CoV-2 in wastewater matched the waves of active cases. In February–April 2021, a viral load of 1.0E+07 GU inh(−1) d [Formula: see text] corresponded to 700 active cases/100,000 inh. In July–September 2021, although the low current active cases, sewage revealed an appreciable SARS-CoV-2 circulation (in this period 2.2E+07 GU inh(−1) d(−1) corresponded to 90 active cases/100,000 inh). Omicron was not detected in wastewater until mid-December 2021. The Omicron spread caused a 5–6 fold increase of the viral load in two weeks, reaching the highest peak (2.0–2.2E+08 GU inh(−1) d(−1) and 4500 active cases/100,000 inh) during the pandemic. In this period, wastewater surveillance anticipated epidemiological data by about 6 days. In winter 2021–22, despite the 4–7 times higher viral loads in wastewater, hospitalizations were 4 times lower than in winter 2020–21 due to the vaccination coverage >80%. The Omicron wave demonstrated that SARS-CoV-2 monitoring of wastewater anticipated epidemiological data, confirming its importance in long-term surveillance. |
format | Online Article Text |
id | pubmed-9122782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Authors. Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91227822022-05-21 The wave of the SARS-CoV-2 Omicron variant resulted in a rapid spike and decline as highlighted by municipal wastewater surveillance Cutrupi, Francesca Cadonna, Maria Manara, Serena Postinghel, Mattia La Rosa, Giuseppina Suffredini, Elisabetta Foladori, Paola Environ Technol Innov Article This paper highlights the extraordinarily rapid spread of SARS-CoV-2 loads in wastewater that during the Omicron wave in December 2021–February 2022, compared with the profiles acquired in 2020–21 with 410 samples from two wastewater treatment plants (Trento+suburbs, 132,500 inhabitants). Monitoring of SARS-CoV-2 in wastewater focused on: (i) 3 samplings/week and analysis, (ii) normalization to calculate genomic units (GU) inh(−1) d(−1); (iii) calculation of a 7-day moving average to smooth daily fluctuations; (iv) comparison with the ‘current active cases’/100,000 inh progressively affected by the mass vaccination. The time profiles of SARS-CoV-2 in wastewater matched the waves of active cases. In February–April 2021, a viral load of 1.0E+07 GU inh(−1) d [Formula: see text] corresponded to 700 active cases/100,000 inh. In July–September 2021, although the low current active cases, sewage revealed an appreciable SARS-CoV-2 circulation (in this period 2.2E+07 GU inh(−1) d(−1) corresponded to 90 active cases/100,000 inh). Omicron was not detected in wastewater until mid-December 2021. The Omicron spread caused a 5–6 fold increase of the viral load in two weeks, reaching the highest peak (2.0–2.2E+08 GU inh(−1) d(−1) and 4500 active cases/100,000 inh) during the pandemic. In this period, wastewater surveillance anticipated epidemiological data by about 6 days. In winter 2021–22, despite the 4–7 times higher viral loads in wastewater, hospitalizations were 4 times lower than in winter 2020–21 due to the vaccination coverage >80%. The Omicron wave demonstrated that SARS-CoV-2 monitoring of wastewater anticipated epidemiological data, confirming its importance in long-term surveillance. The Authors. Published by Elsevier B.V. 2022-11 2022-05-21 /pmc/articles/PMC9122782/ /pubmed/35615435 http://dx.doi.org/10.1016/j.eti.2022.102667 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Cutrupi, Francesca Cadonna, Maria Manara, Serena Postinghel, Mattia La Rosa, Giuseppina Suffredini, Elisabetta Foladori, Paola The wave of the SARS-CoV-2 Omicron variant resulted in a rapid spike and decline as highlighted by municipal wastewater surveillance |
title | The wave of the SARS-CoV-2 Omicron variant resulted in a rapid spike and decline as highlighted by municipal wastewater surveillance |
title_full | The wave of the SARS-CoV-2 Omicron variant resulted in a rapid spike and decline as highlighted by municipal wastewater surveillance |
title_fullStr | The wave of the SARS-CoV-2 Omicron variant resulted in a rapid spike and decline as highlighted by municipal wastewater surveillance |
title_full_unstemmed | The wave of the SARS-CoV-2 Omicron variant resulted in a rapid spike and decline as highlighted by municipal wastewater surveillance |
title_short | The wave of the SARS-CoV-2 Omicron variant resulted in a rapid spike and decline as highlighted by municipal wastewater surveillance |
title_sort | wave of the sars-cov-2 omicron variant resulted in a rapid spike and decline as highlighted by municipal wastewater surveillance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122782/ https://www.ncbi.nlm.nih.gov/pubmed/35615435 http://dx.doi.org/10.1016/j.eti.2022.102667 |
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