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Phase I study of ribociclib and everolimus in children with newly diagnosed DIPG and high-grade glioma: A CONNECT pediatric neuro-oncology consortium report

BACKGROUND: Genomic aberrations in the cell cycle and PI3K/Akt/mTOR pathways have been reported in diffuse intrinsic pontine glioma (DIPG) and high-grade glioma (HGG). Dual inhibition of CDK4/6 and mTOR has biologic rationale and minimal overlapping toxicities. This study determined the recommended...

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Detalles Bibliográficos
Autores principales:	DeWire, Mariko, Lazow, Margot, Campagne, Olivia, Leach, James, Fuller, Christine, Senthil Kumar, Shiva, Stanek, Joseph, de Blank, Peter, Hummel, Trent R, Pillay-Smiley, Natasha, Salloum, Ralph, Stevenson, Charles B, Baxter, Patricia, Gass, David, Goldman, Stewart, Leary, Sarah E S, Carle, Adam, Mikael, Leonie, Crabtree, Dorothy, Chaney, Brooklyn, Lane, Adam, Drissi, Rachid, Stewart, Clinton F, Fouladi, Maryam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Clinical Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122788/ https://www.ncbi.nlm.nih.gov/pubmed/35611273 http://dx.doi.org/10.1093/noajnl/vdac055

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