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Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases

ABSTRACT: Macrolide antibiotics are one of the most commonly used broad-spectrum antibiotics. They have an inhibitory effect on a variety of respiratory pathogens; besides, they have non-anti-infective effects, including anti-inflammatory, regulating airway secretion, immune regulation, and other ef...

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Autores principales: Sun, Jialiang, Li, Yanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122820/
https://www.ncbi.nlm.nih.gov/pubmed/34120139
http://dx.doi.org/10.1038/s41390-021-01613-4
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author Sun, Jialiang
Li, Yanan
author_facet Sun, Jialiang
Li, Yanan
author_sort Sun, Jialiang
collection PubMed
description ABSTRACT: Macrolide antibiotics are one of the most commonly used broad-spectrum antibiotics. They have an inhibitory effect on a variety of respiratory pathogens; besides, they have non-anti-infective effects, including anti-inflammatory, regulating airway secretion, immune regulation, and other effects. A growing number of studies have shown that the non-anti-infective effects of macrolides have important and potential value in the treatment of pediatric chronic airway diseases; the therapy was described as “long-term, low-dose usage”; unfortunately, there is no guideline or consensus that applies to children. To better carry out the mechanism and clinical research of non-anti-infective effect and promote its rational use in children, the authors summarize the evidence of the usage of long-term, low-dose macrolide antibiotic therapy (LLMAT) in the treatment of chronic airway diseases in children and the progress in recent years. IMPACT: This review summarizes the evidence (mostly in recent 5 years) of the usage of long-term, low-dose macrolide antibiotic therapy in the treatment of chronic airway diseases. The recent studies and guidelines support and enrich the point that long-term, low-dose macrolide antibiotic therapy has potential benefit for children with severe asthma, CF, non-CF bronchiectasis, and BO, which provides clinical references and is of clinical interest. Long-term, low-dose macrolide antibiotic therapy has good safety, and no serious events have been reported; however, potential cardiac side effects and macrolide resistance should be clinically noted.
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spelling pubmed-91228202022-05-22 Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases Sun, Jialiang Li, Yanan Pediatr Res Review Article ABSTRACT: Macrolide antibiotics are one of the most commonly used broad-spectrum antibiotics. They have an inhibitory effect on a variety of respiratory pathogens; besides, they have non-anti-infective effects, including anti-inflammatory, regulating airway secretion, immune regulation, and other effects. A growing number of studies have shown that the non-anti-infective effects of macrolides have important and potential value in the treatment of pediatric chronic airway diseases; the therapy was described as “long-term, low-dose usage”; unfortunately, there is no guideline or consensus that applies to children. To better carry out the mechanism and clinical research of non-anti-infective effect and promote its rational use in children, the authors summarize the evidence of the usage of long-term, low-dose macrolide antibiotic therapy (LLMAT) in the treatment of chronic airway diseases in children and the progress in recent years. IMPACT: This review summarizes the evidence (mostly in recent 5 years) of the usage of long-term, low-dose macrolide antibiotic therapy in the treatment of chronic airway diseases. The recent studies and guidelines support and enrich the point that long-term, low-dose macrolide antibiotic therapy has potential benefit for children with severe asthma, CF, non-CF bronchiectasis, and BO, which provides clinical references and is of clinical interest. Long-term, low-dose macrolide antibiotic therapy has good safety, and no serious events have been reported; however, potential cardiac side effects and macrolide resistance should be clinically noted. Nature Publishing Group US 2021-06-12 2022 /pmc/articles/PMC9122820/ /pubmed/34120139 http://dx.doi.org/10.1038/s41390-021-01613-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Sun, Jialiang
Li, Yanan
Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases
title Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases
title_full Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases
title_fullStr Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases
title_full_unstemmed Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases
title_short Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases
title_sort long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122820/
https://www.ncbi.nlm.nih.gov/pubmed/34120139
http://dx.doi.org/10.1038/s41390-021-01613-4
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