Animal models for studying coronavirus infections and developing antiviral agents and vaccines

In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly coronavirus that infects humans and causes the new coronavirus disease (COVID-19). COVID-19 has already caused more than six mil...

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Autores principales: Lin, Qisheng, Lu, Chunni, Hong, Yuqi, Li, Runfeng, Chen, Jinding, Chen, Weisan, Chen, Jianxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122840/
https://www.ncbi.nlm.nih.gov/pubmed/35605699
http://dx.doi.org/10.1016/j.antiviral.2022.105345
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author Lin, Qisheng
Lu, Chunni
Hong, Yuqi
Li, Runfeng
Chen, Jinding
Chen, Weisan
Chen, Jianxin
author_facet Lin, Qisheng
Lu, Chunni
Hong, Yuqi
Li, Runfeng
Chen, Jinding
Chen, Weisan
Chen, Jianxin
author_sort Lin, Qisheng
collection PubMed
description In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly coronavirus that infects humans and causes the new coronavirus disease (COVID-19). COVID-19 has already caused more than six million deaths worldwide and it is likely the biggest pandemic of this century faced by mankind. Although many studies on SARS-CoV-2 have been conducted, a detailed understanding of SARS-CoV-2 and COVID-19 is still lacking. Animal models are indispensable for studying its pathogenesis and developing vaccines and antivirals. In this review, we analyze animal models of coronavirus infections and explore their applications on antivirals and vaccines.
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spelling pubmed-91228402022-05-21 Animal models for studying coronavirus infections and developing antiviral agents and vaccines Lin, Qisheng Lu, Chunni Hong, Yuqi Li, Runfeng Chen, Jinding Chen, Weisan Chen, Jianxin Antiviral Res Article In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly coronavirus that infects humans and causes the new coronavirus disease (COVID-19). COVID-19 has already caused more than six million deaths worldwide and it is likely the biggest pandemic of this century faced by mankind. Although many studies on SARS-CoV-2 have been conducted, a detailed understanding of SARS-CoV-2 and COVID-19 is still lacking. Animal models are indispensable for studying its pathogenesis and developing vaccines and antivirals. In this review, we analyze animal models of coronavirus infections and explore their applications on antivirals and vaccines. Elsevier B.V. 2022-07 2022-05-21 /pmc/articles/PMC9122840/ /pubmed/35605699 http://dx.doi.org/10.1016/j.antiviral.2022.105345 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Lin, Qisheng
Lu, Chunni
Hong, Yuqi
Li, Runfeng
Chen, Jinding
Chen, Weisan
Chen, Jianxin
Animal models for studying coronavirus infections and developing antiviral agents and vaccines
title Animal models for studying coronavirus infections and developing antiviral agents and vaccines
title_full Animal models for studying coronavirus infections and developing antiviral agents and vaccines
title_fullStr Animal models for studying coronavirus infections and developing antiviral agents and vaccines
title_full_unstemmed Animal models for studying coronavirus infections and developing antiviral agents and vaccines
title_short Animal models for studying coronavirus infections and developing antiviral agents and vaccines
title_sort animal models for studying coronavirus infections and developing antiviral agents and vaccines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122840/
https://www.ncbi.nlm.nih.gov/pubmed/35605699
http://dx.doi.org/10.1016/j.antiviral.2022.105345
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