Cargando…

Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study

The endothelium and the glycocalyx play a pivotal role in regulating microvascular function and perfusion in health and critical illness. It is unknown today, whether aerobic exercise immediately affects dimensions of the endothelial surface layer (ESL) in relation to microvascular perfusion as a ph...

Descripción completa

Detalles Bibliográficos
Autores principales: Fuchs, Alexander, Neumann, Tobias, Drinhaus, Hendrik, Herrmann, Anika, Vink, Hans, Annecke, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122854/
https://www.ncbi.nlm.nih.gov/pubmed/33534119
http://dx.doi.org/10.1007/s10877-021-00660-w
_version_ 1784711434570039296
author Fuchs, Alexander
Neumann, Tobias
Drinhaus, Hendrik
Herrmann, Anika
Vink, Hans
Annecke, Thorsten
author_facet Fuchs, Alexander
Neumann, Tobias
Drinhaus, Hendrik
Herrmann, Anika
Vink, Hans
Annecke, Thorsten
author_sort Fuchs, Alexander
collection PubMed
description The endothelium and the glycocalyx play a pivotal role in regulating microvascular function and perfusion in health and critical illness. It is unknown today, whether aerobic exercise immediately affects dimensions of the endothelial surface layer (ESL) in relation to microvascular perfusion as a physiologic adaption to increased nutritional demands. This monocentric observational study was designed to determine real-time ESL and perfusion measurements of the sublingual microcirculation using sidestream dark field imaging performed in 14 healthy subjects before and after completing a 10 km trial running distance. A novel image acquisition and analysis software automatically analysed the perfused boundary region (PBR), an inverse parameter for red blood cell (RBC) penetration of the ESL, in vessels between 5 and 25 µm diameter. Microvascular perfusion was assessed by calculating RBC filling percentage. There was no significant immediate effect of exercise on PBR and RBC filling percentage. Linear regression analysis revealed a distinct association between change of PBR and change of RBC filling percentage (regression coefficient β: − 0.026; 95% confidence interval − 0.043 to − 0.009; p = 0.006). A single aerobic exercise did not induce a change of PBR or RBC filling percentage. The endothelium of the microvasculature facilitates efficient perfusion in vessels reacting with an increased endothelial surface layer.
format Online
Article
Text
id pubmed-9122854
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-91228542022-05-22 Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study Fuchs, Alexander Neumann, Tobias Drinhaus, Hendrik Herrmann, Anika Vink, Hans Annecke, Thorsten J Clin Monit Comput Original Research The endothelium and the glycocalyx play a pivotal role in regulating microvascular function and perfusion in health and critical illness. It is unknown today, whether aerobic exercise immediately affects dimensions of the endothelial surface layer (ESL) in relation to microvascular perfusion as a physiologic adaption to increased nutritional demands. This monocentric observational study was designed to determine real-time ESL and perfusion measurements of the sublingual microcirculation using sidestream dark field imaging performed in 14 healthy subjects before and after completing a 10 km trial running distance. A novel image acquisition and analysis software automatically analysed the perfused boundary region (PBR), an inverse parameter for red blood cell (RBC) penetration of the ESL, in vessels between 5 and 25 µm diameter. Microvascular perfusion was assessed by calculating RBC filling percentage. There was no significant immediate effect of exercise on PBR and RBC filling percentage. Linear regression analysis revealed a distinct association between change of PBR and change of RBC filling percentage (regression coefficient β: − 0.026; 95% confidence interval − 0.043 to − 0.009; p = 0.006). A single aerobic exercise did not induce a change of PBR or RBC filling percentage. The endothelium of the microvasculature facilitates efficient perfusion in vessels reacting with an increased endothelial surface layer. Springer Netherlands 2021-02-03 2022 /pmc/articles/PMC9122854/ /pubmed/33534119 http://dx.doi.org/10.1007/s10877-021-00660-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Research
Fuchs, Alexander
Neumann, Tobias
Drinhaus, Hendrik
Herrmann, Anika
Vink, Hans
Annecke, Thorsten
Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study
title Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study
title_full Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study
title_fullStr Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study
title_full_unstemmed Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study
title_short Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study
title_sort effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122854/
https://www.ncbi.nlm.nih.gov/pubmed/33534119
http://dx.doi.org/10.1007/s10877-021-00660-w
work_keys_str_mv AT fuchsalexander effectsofasingleaerobicexerciseonperfusedboundaryregionandmicrovascularperfusionafieldstudy
AT neumanntobias effectsofasingleaerobicexerciseonperfusedboundaryregionandmicrovascularperfusionafieldstudy
AT drinhaushendrik effectsofasingleaerobicexerciseonperfusedboundaryregionandmicrovascularperfusionafieldstudy
AT herrmannanika effectsofasingleaerobicexerciseonperfusedboundaryregionandmicrovascularperfusionafieldstudy
AT vinkhans effectsofasingleaerobicexerciseonperfusedboundaryregionandmicrovascularperfusionafieldstudy
AT anneckethorsten effectsofasingleaerobicexerciseonperfusedboundaryregionandmicrovascularperfusionafieldstudy