SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis

Stimulator of interferon genes (STING) activation induces type I interferons and pro-inflammatory cytokines which stimulate tumor antigen cross presentation and the adaptive immune responses against tumor. The first-generation of STING agonists, cyclic di-nucleotide (CDN), mimicked the endogenous ST...

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Detalles Bibliográficos
Autores principales: Song, Chunying, Liu, Dong, Liu, Suxing, Li, Di, Horecny, Ivana, Zhang, Xinzhu, Li, Puhui, Chen, Lei, Miller, Matthew, Chowdhury, Rasheduzzaman, Issa, Mena, Shen, Ru, Yan, Yinfa, Zhang, Fengqi, Zhang, Lei, Zhang, Limin, Bai, Chang, Feng, Jun, Zhuang, Linghang, Zhang, Rumin, Li, Jing, Wilkinson, Hilary, Liu, Jian, Tao, Weikang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122897/
https://www.ncbi.nlm.nih.gov/pubmed/35595822
http://dx.doi.org/10.1038/s41598-022-12449-1

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