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Insights into the client protein release mechanism of the ATP-independent chaperone Spy

Molecular chaperones play a central role in regulating protein homeostasis, and their active forms often contain intrinsically disordered regions (IDRs). However, how IDRs impact chaperone action remains poorly understood. Here, we discover that the disordered N terminus of the prototype chaperone S...

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Detalles Bibliográficos
Autores principales:	He, Wei, Li, Xinming, Xue, Hongjuan, Yang, Yuanyuan, Mencius, Jun, Bai, Ling, Zhang, Jiayin, Xu, Jianhe, Wu, Bin, Xue, Yi, Quan, Shu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122904/ https://www.ncbi.nlm.nih.gov/pubmed/35595811 http://dx.doi.org/10.1038/s41467-022-30499-x

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