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Engineered Cas12i2 is a versatile high-efficiency platform for therapeutic genome editing

The CRISPR-Cas type V-I is a family of Cas12i-containing programmable nuclease systems guided by a short crRNA without requirement for a tracrRNA. Here we present an engineered Type V-I CRISPR system (Cas12i), ABR-001, which utilizes a tracr-less guide RNA. The compact Cas12i effector is capable of...

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Detalles Bibliográficos
Autores principales:	McGaw, Colin, Garrity, Anthony J., Munoz, Gabrielle Z., Haswell, Jeffrey R., Sengupta, Sejuti, Keston-Smith, Elise, Hunnewell, Pratyusha, Ornstein, Alexa, Bose, Mishti, Wessells, Quinton, Jakimo, Noah, Yan, Paul, Zhang, Huaibin, Alfonse, Lauren E., Ziblat, Roy, Carte, Jason M., Lu, Wei-Cheng, Cerchione, Derek, Hilbert, Brendan, Sothiselvam, Shanmugapriya, Yan, Winston X., Cheng, David R., Scott, David A., DiTommaso, Tia, Chong, Shaorong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122993/ https://www.ncbi.nlm.nih.gov/pubmed/35595757 http://dx.doi.org/10.1038/s41467-022-30465-7

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