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Effect of central and peripheral cone- and rod-specific stimulation on the pupillary light reflex
PURPOSE: To assess the effect of central and peripheral stimulation on the pupillary light reflex. The aim was to detect possible differences between cone- and rod-driven reactions. METHODS: Relative maximal pupil constriction amplitude (relMCA) and latency to constriction onset (latency) to cone- a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123028/ https://www.ncbi.nlm.nih.gov/pubmed/34826023 http://dx.doi.org/10.1007/s10792-021-02132-1 |
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author | Sonntag, Anton Kelbsch, Carina Jung, Ronja Wilhelm, Helmut Strasser, Torsten Peters, Tobias Stingl, Krunoslav Wilhelm, Barbara |
author_facet | Sonntag, Anton Kelbsch, Carina Jung, Ronja Wilhelm, Helmut Strasser, Torsten Peters, Tobias Stingl, Krunoslav Wilhelm, Barbara |
author_sort | Sonntag, Anton |
collection | PubMed |
description | PURPOSE: To assess the effect of central and peripheral stimulation on the pupillary light reflex. The aim was to detect possible differences between cone- and rod-driven reactions. METHODS: Relative maximal pupil constriction amplitude (relMCA) and latency to constriction onset (latency) to cone- and rod-specific stimuli of 30 healthy participants (24 ± 5 years (standard deviation)) were measured using chromatic pupil campimetry. Cone- and rod-specific stimuli had different intensities and wavelengths according to the Standards in Pupillography. Five filled circles with radii of 3°, 5°, 10°, 20° and 40° and four rings with a constant outer radius of 40° and inner radii of 3°, 5°, 10° and 20° were used as stimuli. RESULTS: For cone-and rod-specific stimuli, relMCA increased with the stimulus area for both, circles and rings. However, increasing the area of a cone-specific ring by minimizing its inner radius with constant outer radius increased relMCA significantly stronger than the same did for a rod-specific ring. For cones and rods, a circle stimulus with a radius of 40° created a lower relMCA than the summation of the relMCAs to the corresponding ring and circle stimuli which combined create a 40° circle-stimulus. Latency was longer for rods than for cones. It decreased with increasing stimulus area for circle stimuli while it stayed nearly constant with increasing ring stimulus area for cone- and rod-specific stimuli. CONCLUSION: The effect of central stimulation on relMCA is more dominant for cone-specific stimuli than for rod-specific stimuli while latency dynamics are similar for both conditions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10792-021-02132-1. |
format | Online Article Text |
id | pubmed-9123028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-91230282022-05-22 Effect of central and peripheral cone- and rod-specific stimulation on the pupillary light reflex Sonntag, Anton Kelbsch, Carina Jung, Ronja Wilhelm, Helmut Strasser, Torsten Peters, Tobias Stingl, Krunoslav Wilhelm, Barbara Int Ophthalmol Original Paper PURPOSE: To assess the effect of central and peripheral stimulation on the pupillary light reflex. The aim was to detect possible differences between cone- and rod-driven reactions. METHODS: Relative maximal pupil constriction amplitude (relMCA) and latency to constriction onset (latency) to cone- and rod-specific stimuli of 30 healthy participants (24 ± 5 years (standard deviation)) were measured using chromatic pupil campimetry. Cone- and rod-specific stimuli had different intensities and wavelengths according to the Standards in Pupillography. Five filled circles with radii of 3°, 5°, 10°, 20° and 40° and four rings with a constant outer radius of 40° and inner radii of 3°, 5°, 10° and 20° were used as stimuli. RESULTS: For cone-and rod-specific stimuli, relMCA increased with the stimulus area for both, circles and rings. However, increasing the area of a cone-specific ring by minimizing its inner radius with constant outer radius increased relMCA significantly stronger than the same did for a rod-specific ring. For cones and rods, a circle stimulus with a radius of 40° created a lower relMCA than the summation of the relMCAs to the corresponding ring and circle stimuli which combined create a 40° circle-stimulus. Latency was longer for rods than for cones. It decreased with increasing stimulus area for circle stimuli while it stayed nearly constant with increasing ring stimulus area for cone- and rod-specific stimuli. CONCLUSION: The effect of central stimulation on relMCA is more dominant for cone-specific stimuli than for rod-specific stimuli while latency dynamics are similar for both conditions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10792-021-02132-1. Springer Netherlands 2021-11-26 2022 /pmc/articles/PMC9123028/ /pubmed/34826023 http://dx.doi.org/10.1007/s10792-021-02132-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Paper Sonntag, Anton Kelbsch, Carina Jung, Ronja Wilhelm, Helmut Strasser, Torsten Peters, Tobias Stingl, Krunoslav Wilhelm, Barbara Effect of central and peripheral cone- and rod-specific stimulation on the pupillary light reflex |
title | Effect of central and peripheral cone- and rod-specific stimulation on the pupillary light reflex |
title_full | Effect of central and peripheral cone- and rod-specific stimulation on the pupillary light reflex |
title_fullStr | Effect of central and peripheral cone- and rod-specific stimulation on the pupillary light reflex |
title_full_unstemmed | Effect of central and peripheral cone- and rod-specific stimulation on the pupillary light reflex |
title_short | Effect of central and peripheral cone- and rod-specific stimulation on the pupillary light reflex |
title_sort | effect of central and peripheral cone- and rod-specific stimulation on the pupillary light reflex |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123028/ https://www.ncbi.nlm.nih.gov/pubmed/34826023 http://dx.doi.org/10.1007/s10792-021-02132-1 |
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