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Immune checkpoint inhibitor–associated myocarditis: Case reports and a review of the literature
Immune checkpoint inhibitors (ICIs) are increasingly recognised to effectuate long-lasting therapeutic responses in solid tumours. However, ICI therapy can also result in various immune-related adverse events, such as ICI-associated myocarditis, a rare but serious complication. The clinical spectrum...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bohn Stafleu van Loghum
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123105/ https://www.ncbi.nlm.nih.gov/pubmed/35061242 http://dx.doi.org/10.1007/s12471-021-01655-7 |
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author | Osinga, T. E. Oosting, S. F. van der Meer, P. de Boer, R. A. Kuenen, B. C. Rutgers, A. Bergmann, L. Oude Munnink, T. H. Jalving, M. van Kruchten, M. |
author_facet | Osinga, T. E. Oosting, S. F. van der Meer, P. de Boer, R. A. Kuenen, B. C. Rutgers, A. Bergmann, L. Oude Munnink, T. H. Jalving, M. van Kruchten, M. |
author_sort | Osinga, T. E. |
collection | PubMed |
description | Immune checkpoint inhibitors (ICIs) are increasingly recognised to effectuate long-lasting therapeutic responses in solid tumours. However, ICI therapy can also result in various immune-related adverse events, such as ICI-associated myocarditis, a rare but serious complication. The clinical spectrum is wide and includes asymptomatic patients and patients with fulminant heart failure, making it challenging to diagnose this condition. Furthermore, the optimal diagnostic algorithm and treatment of ICI-associated myocarditis is unknown. In this review, we describe two cases on both ends of the spectrum and discuss the challenges in recognising, diagnosing and treating ICI-associated myocarditis. |
format | Online Article Text |
id | pubmed-9123105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Bohn Stafleu van Loghum |
record_format | MEDLINE/PubMed |
spelling | pubmed-91231052022-05-22 Immune checkpoint inhibitor–associated myocarditis: Case reports and a review of the literature Osinga, T. E. Oosting, S. F. van der Meer, P. de Boer, R. A. Kuenen, B. C. Rutgers, A. Bergmann, L. Oude Munnink, T. H. Jalving, M. van Kruchten, M. Neth Heart J Review Article Immune checkpoint inhibitors (ICIs) are increasingly recognised to effectuate long-lasting therapeutic responses in solid tumours. However, ICI therapy can also result in various immune-related adverse events, such as ICI-associated myocarditis, a rare but serious complication. The clinical spectrum is wide and includes asymptomatic patients and patients with fulminant heart failure, making it challenging to diagnose this condition. Furthermore, the optimal diagnostic algorithm and treatment of ICI-associated myocarditis is unknown. In this review, we describe two cases on both ends of the spectrum and discuss the challenges in recognising, diagnosing and treating ICI-associated myocarditis. Bohn Stafleu van Loghum 2022-01-21 2022-06 /pmc/articles/PMC9123105/ /pubmed/35061242 http://dx.doi.org/10.1007/s12471-021-01655-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Osinga, T. E. Oosting, S. F. van der Meer, P. de Boer, R. A. Kuenen, B. C. Rutgers, A. Bergmann, L. Oude Munnink, T. H. Jalving, M. van Kruchten, M. Immune checkpoint inhibitor–associated myocarditis: Case reports and a review of the literature |
title | Immune checkpoint inhibitor–associated myocarditis: Case reports and a review of the literature |
title_full | Immune checkpoint inhibitor–associated myocarditis: Case reports and a review of the literature |
title_fullStr | Immune checkpoint inhibitor–associated myocarditis: Case reports and a review of the literature |
title_full_unstemmed | Immune checkpoint inhibitor–associated myocarditis: Case reports and a review of the literature |
title_short | Immune checkpoint inhibitor–associated myocarditis: Case reports and a review of the literature |
title_sort | immune checkpoint inhibitor–associated myocarditis: case reports and a review of the literature |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123105/ https://www.ncbi.nlm.nih.gov/pubmed/35061242 http://dx.doi.org/10.1007/s12471-021-01655-7 |
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