Long noncoding RNAs as regulators of pediatric acute myeloid leukemia

Long noncoding RNAs (lncRNAs) are increasingly emerging as regulators across human development and disease, and many have been described in the context of hematopoiesis and leukemogenesis. These studies have yielded new molecular insights into the contribution of lncRNAs to AML development and revea...

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Autores principales: Neyazi, Sina, Ng, Michelle, Heckl, Dirk, Klusmann, Jan-Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123150/
https://www.ncbi.nlm.nih.gov/pubmed/35596093
http://dx.doi.org/10.1186/s40348-022-00142-2
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author Neyazi, Sina
Ng, Michelle
Heckl, Dirk
Klusmann, Jan-Henning
author_facet Neyazi, Sina
Ng, Michelle
Heckl, Dirk
Klusmann, Jan-Henning
author_sort Neyazi, Sina
collection PubMed
description Long noncoding RNAs (lncRNAs) are increasingly emerging as regulators across human development and disease, and many have been described in the context of hematopoiesis and leukemogenesis. These studies have yielded new molecular insights into the contribution of lncRNAs to AML development and revealed connections between lncRNA expression and clinical parameters in AML patients. In this mini review, we illustrate the versatile functions of lncRNAs in AML, with a focus on pediatric AML, and present examples that may serve as future therapeutic targets or predictive factors.
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spelling pubmed-91231502022-05-22 Long noncoding RNAs as regulators of pediatric acute myeloid leukemia Neyazi, Sina Ng, Michelle Heckl, Dirk Klusmann, Jan-Henning Mol Cell Pediatr Mini Review Long noncoding RNAs (lncRNAs) are increasingly emerging as regulators across human development and disease, and many have been described in the context of hematopoiesis and leukemogenesis. These studies have yielded new molecular insights into the contribution of lncRNAs to AML development and revealed connections between lncRNA expression and clinical parameters in AML patients. In this mini review, we illustrate the versatile functions of lncRNAs in AML, with a focus on pediatric AML, and present examples that may serve as future therapeutic targets or predictive factors. Springer International Publishing 2022-05-20 /pmc/articles/PMC9123150/ /pubmed/35596093 http://dx.doi.org/10.1186/s40348-022-00142-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mini Review
Neyazi, Sina
Ng, Michelle
Heckl, Dirk
Klusmann, Jan-Henning
Long noncoding RNAs as regulators of pediatric acute myeloid leukemia
title Long noncoding RNAs as regulators of pediatric acute myeloid leukemia
title_full Long noncoding RNAs as regulators of pediatric acute myeloid leukemia
title_fullStr Long noncoding RNAs as regulators of pediatric acute myeloid leukemia
title_full_unstemmed Long noncoding RNAs as regulators of pediatric acute myeloid leukemia
title_short Long noncoding RNAs as regulators of pediatric acute myeloid leukemia
title_sort long noncoding rnas as regulators of pediatric acute myeloid leukemia
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123150/
https://www.ncbi.nlm.nih.gov/pubmed/35596093
http://dx.doi.org/10.1186/s40348-022-00142-2
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