EGLN1 prolyl hydroxylation of hypoxia-induced transcription factor HIF1α is repressed by SET7-catalyzed lysine methylation

Egg-laying defective nine 1 (EGLN1) functions as an oxygen sensor to catalyze prolyl hydroxylation of the transcription factor hypoxia-inducible factor-1 α under normoxia conditions, leading to its proteasomal degradation. Thus, EGLN1 plays a central role in the hypoxia-inducible factor–mediated hyp...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Jinhua, Deng, Hongyan, Wang, Zixuan, Zha, Huangyuan, Liao, Qian, Zhu, Chunchun, Chen, Xiaoyun, Sun, Xueyi, Jia, Shuke, Ouyang, Gang, Liu, Xing, Xiao, Wuhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123262/
https://www.ncbi.nlm.nih.gov/pubmed/35452683
http://dx.doi.org/10.1016/j.jbc.2022.101961

Ejemplares similares

Ejemplares similares