Beta-hydroxybutyrate dampens adipose progenitors’ profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36-dependent mechanisms

BACKGROUND/PURPOSE: Adipose tissue contains progenitor cells that contribute to beneficial tissue expansion when needed by de novo adipocyte formation (classical white or beige fat cells with thermogenic potential). However, in chronic obesity, they can exhibit an activated pro-fibrotic, extracellul...

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Detalles Bibliográficos
Autores principales: Lecoutre, Simon, Merabtene, Fatiha, El Hachem, Elie-Julien, Gamblin, Camille, Rouault, Christine, Sokolovska, Nataliya, Soula, Hedi, Lai, Wi S., Blackshear, Perry J., Clément, Karine, Dugail, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123279/
https://www.ncbi.nlm.nih.gov/pubmed/35550189
http://dx.doi.org/10.1016/j.molmet.2022.101512

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