Cargando…
A Potential Prognostic Marker PRDM1 in Pancreatic Adenocarcinoma
Pancreatic adenocarcinoma (PAAD) is a major threat to people's health. PRDM1 is a transcription factor with multiple functions, and its functions have been validated in a variety of tumors; however, there are few studies reported on PRDM1 in PAAD. Using the GEPIA2 database, this research found...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123419/ https://www.ncbi.nlm.nih.gov/pubmed/35607327 http://dx.doi.org/10.1155/2022/1934381 |
_version_ | 1784711550929469440 |
---|---|
author | Zhou, Bo Zhang, Jie Zhu, Hongda Wu, Shugeng |
author_facet | Zhou, Bo Zhang, Jie Zhu, Hongda Wu, Shugeng |
author_sort | Zhou, Bo |
collection | PubMed |
description | Pancreatic adenocarcinoma (PAAD) is a major threat to people's health. PRDM1 is a transcription factor with multiple functions, and its functions have been validated in a variety of tumors; however, there are few studies reported on PRDM1 in PAAD. Using the GEPIA2 database, this research found that PRDM1 expression in PAAD was significantly higher than that in normal pancreatic tissue. The Kaplan-Meier Plotter database showed that high expression of PRDM1 in PAAD has a poor prognosis, suggesting that PRDM1 may be a potential prognostic marker in PAAD. The cBioPortal database shows that the expression of PRDM1 in PAAD is significantly correlated with its methylation degree. Further analysis on the coexpressed genes of PRDM1 in PAAD was performed by using LinkedOmics database to explore potential mechanisms. Based on gene enrichment analysis, PRDM1 was implicated in many pathways involved in tumor progression. In the construction of a PPI network of PRDM1 and its coexpressed gene protein via the STRING database, we found that PRDM1 may be involved in the pathogenesis and development of PAAD. TIMER database suggested that a high level of PRDM1 has a significant positive correlation with macrophages, neutrophils, and DCs. Potential methylation sites of PRDM1 were found through DNMIVD database, and MethSurv database explored eight sites which were significantly related with the prognosis of PAAD. In conclusion, PRDM1 may work as a prognostic marker or even provide a potential therapeutic strategy in PAAD. |
format | Online Article Text |
id | pubmed-9123419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-91234192022-05-22 A Potential Prognostic Marker PRDM1 in Pancreatic Adenocarcinoma Zhou, Bo Zhang, Jie Zhu, Hongda Wu, Shugeng J Oncol Research Article Pancreatic adenocarcinoma (PAAD) is a major threat to people's health. PRDM1 is a transcription factor with multiple functions, and its functions have been validated in a variety of tumors; however, there are few studies reported on PRDM1 in PAAD. Using the GEPIA2 database, this research found that PRDM1 expression in PAAD was significantly higher than that in normal pancreatic tissue. The Kaplan-Meier Plotter database showed that high expression of PRDM1 in PAAD has a poor prognosis, suggesting that PRDM1 may be a potential prognostic marker in PAAD. The cBioPortal database shows that the expression of PRDM1 in PAAD is significantly correlated with its methylation degree. Further analysis on the coexpressed genes of PRDM1 in PAAD was performed by using LinkedOmics database to explore potential mechanisms. Based on gene enrichment analysis, PRDM1 was implicated in many pathways involved in tumor progression. In the construction of a PPI network of PRDM1 and its coexpressed gene protein via the STRING database, we found that PRDM1 may be involved in the pathogenesis and development of PAAD. TIMER database suggested that a high level of PRDM1 has a significant positive correlation with macrophages, neutrophils, and DCs. Potential methylation sites of PRDM1 were found through DNMIVD database, and MethSurv database explored eight sites which were significantly related with the prognosis of PAAD. In conclusion, PRDM1 may work as a prognostic marker or even provide a potential therapeutic strategy in PAAD. Hindawi 2022-05-13 /pmc/articles/PMC9123419/ /pubmed/35607327 http://dx.doi.org/10.1155/2022/1934381 Text en Copyright © 2022 Bo Zhou et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhou, Bo Zhang, Jie Zhu, Hongda Wu, Shugeng A Potential Prognostic Marker PRDM1 in Pancreatic Adenocarcinoma |
title | A Potential Prognostic Marker PRDM1 in Pancreatic Adenocarcinoma |
title_full | A Potential Prognostic Marker PRDM1 in Pancreatic Adenocarcinoma |
title_fullStr | A Potential Prognostic Marker PRDM1 in Pancreatic Adenocarcinoma |
title_full_unstemmed | A Potential Prognostic Marker PRDM1 in Pancreatic Adenocarcinoma |
title_short | A Potential Prognostic Marker PRDM1 in Pancreatic Adenocarcinoma |
title_sort | potential prognostic marker prdm1 in pancreatic adenocarcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123419/ https://www.ncbi.nlm.nih.gov/pubmed/35607327 http://dx.doi.org/10.1155/2022/1934381 |
work_keys_str_mv | AT zhoubo apotentialprognosticmarkerprdm1inpancreaticadenocarcinoma AT zhangjie apotentialprognosticmarkerprdm1inpancreaticadenocarcinoma AT zhuhongda apotentialprognosticmarkerprdm1inpancreaticadenocarcinoma AT wushugeng apotentialprognosticmarkerprdm1inpancreaticadenocarcinoma AT zhoubo potentialprognosticmarkerprdm1inpancreaticadenocarcinoma AT zhangjie potentialprognosticmarkerprdm1inpancreaticadenocarcinoma AT zhuhongda potentialprognosticmarkerprdm1inpancreaticadenocarcinoma AT wushugeng potentialprognosticmarkerprdm1inpancreaticadenocarcinoma |