Synthesis and antimicrobial activity of N-(indol-5-yl)trifluoroacetamides and indol-5-ylaminium trifluoroacetates substituted in the pyrrole ring

Based on a series of 1H-indol-5-ylamines substituted in the pyrrole ring, the corresponding N-(indol-5-yl)trifluoroacetamides and indol-5-ylaminium trifluoroacetates were prepared. An in silico study showed a wide range of their biological activity, including antimicrobial, antiviral, antiprotozoal, anthelmintic, and antifungal effects. The results of in silico and in vitro screening for antimicrobial activity correlate with each other. All compounds are capable of inhibiting the growth of the tested microorganism strains. The dependence of minimum inhibitory concentrations on the nature of the substituents at the benzene and pyrrole rings of the indole system was revealed.