Cargando…
Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy
BACKGROUND: Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes. DR involves a state of systemic inflammation, and chronic inflammation can promote microvascular and macrovascular diseases in diabetic patients and accelerate disease progression. Ultrawide-fiel...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123654/ https://www.ncbi.nlm.nih.gov/pubmed/35597915 http://dx.doi.org/10.1186/s12886-022-02442-7 |
_version_ | 1784711596779503616 |
---|---|
author | Huang, Lili Li, Lele Wang, Min Zhang, Dongmei Song, Yu |
author_facet | Huang, Lili Li, Lele Wang, Min Zhang, Dongmei Song, Yu |
author_sort | Huang, Lili |
collection | PubMed |
description | BACKGROUND: Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes. DR involves a state of systemic inflammation, and chronic inflammation can promote microvascular and macrovascular diseases in diabetic patients and accelerate disease progression. Ultrawide-field FFA (UWFA) systems are increasingly being used to examine a wider retina. The aim of this study was to explore the correlation between the different manifestations of retinopathy under UWFA and the systemic indicators of white blood cells in patients with diabetic retinopathy. METHODS: This retrospective study included the hospitalized DR patients in the Department of Ophthalmology and Endocrinology of the Affiliated Hospital 2 of Nantong University between January 2016 and March 2019. This study examined the correlations between the UWFA examination results and glycated hemoglobin (HbA1c), routine blood tests,and the neutrophil-to-lymphocyte ratio of patients with clinically diagnosed DR during hospitalization. RESULTS: A total of 115 patients with DR (53 females and 62 males) were included (199 eyes: 102 right eyes and 97 left eyes). UWFA revealed that most eyes (77.4%) had grade 4 microvascular leakage, 52.8% had grade 0 capillary non-perfusion area, 59.3% had grade 0 neovascularization, and 92.0% had grade 0 fibrous proliferative membranes. Microvascular leakage was correlated with the NLR (r = 0.186, P = 0.027). Capillary non-perfusion area was correlated with the monocyte ratio (r = 0.144, P = 0.042) and the eosinophil ratio (r = 0.123, P = 0.044). Neovascularization was correlated to the monocyte ratio (r = 0.324, P = 0.018). Finally, the fibrous proliferative membrane was correlated to the monocyte ratio (r = 0.418, P = 0.002). Only the eosinophil ratio was independently associated with proliferative DR (odds ratio = 1.25, 95% confidence interval: 1.04–1.51, P = 0.018). CONCLUSION: The results of UWFA imaging in patients with DR are correlated with white blood cell population indexes. The eosinophil ratio was independently associated with proliferative DR. |
format | Online Article Text |
id | pubmed-9123654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91236542022-05-22 Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy Huang, Lili Li, Lele Wang, Min Zhang, Dongmei Song, Yu BMC Ophthalmol Research BACKGROUND: Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes. DR involves a state of systemic inflammation, and chronic inflammation can promote microvascular and macrovascular diseases in diabetic patients and accelerate disease progression. Ultrawide-field FFA (UWFA) systems are increasingly being used to examine a wider retina. The aim of this study was to explore the correlation between the different manifestations of retinopathy under UWFA and the systemic indicators of white blood cells in patients with diabetic retinopathy. METHODS: This retrospective study included the hospitalized DR patients in the Department of Ophthalmology and Endocrinology of the Affiliated Hospital 2 of Nantong University between January 2016 and March 2019. This study examined the correlations between the UWFA examination results and glycated hemoglobin (HbA1c), routine blood tests,and the neutrophil-to-lymphocyte ratio of patients with clinically diagnosed DR during hospitalization. RESULTS: A total of 115 patients with DR (53 females and 62 males) were included (199 eyes: 102 right eyes and 97 left eyes). UWFA revealed that most eyes (77.4%) had grade 4 microvascular leakage, 52.8% had grade 0 capillary non-perfusion area, 59.3% had grade 0 neovascularization, and 92.0% had grade 0 fibrous proliferative membranes. Microvascular leakage was correlated with the NLR (r = 0.186, P = 0.027). Capillary non-perfusion area was correlated with the monocyte ratio (r = 0.144, P = 0.042) and the eosinophil ratio (r = 0.123, P = 0.044). Neovascularization was correlated to the monocyte ratio (r = 0.324, P = 0.018). Finally, the fibrous proliferative membrane was correlated to the monocyte ratio (r = 0.418, P = 0.002). Only the eosinophil ratio was independently associated with proliferative DR (odds ratio = 1.25, 95% confidence interval: 1.04–1.51, P = 0.018). CONCLUSION: The results of UWFA imaging in patients with DR are correlated with white blood cell population indexes. The eosinophil ratio was independently associated with proliferative DR. BioMed Central 2022-05-21 /pmc/articles/PMC9123654/ /pubmed/35597915 http://dx.doi.org/10.1186/s12886-022-02442-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Huang, Lili Li, Lele Wang, Min Zhang, Dongmei Song, Yu Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy |
title | Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy |
title_full | Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy |
title_fullStr | Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy |
title_full_unstemmed | Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy |
title_short | Correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy |
title_sort | correlation between ultrawide-field fluorescence contrast results and white blood cell indexes in diabetic retinopathy |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123654/ https://www.ncbi.nlm.nih.gov/pubmed/35597915 http://dx.doi.org/10.1186/s12886-022-02442-7 |
work_keys_str_mv | AT huanglili correlationbetweenultrawidefieldfluorescencecontrastresultsandwhitebloodcellindexesindiabeticretinopathy AT lilele correlationbetweenultrawidefieldfluorescencecontrastresultsandwhitebloodcellindexesindiabeticretinopathy AT wangmin correlationbetweenultrawidefieldfluorescencecontrastresultsandwhitebloodcellindexesindiabeticretinopathy AT zhangdongmei correlationbetweenultrawidefieldfluorescencecontrastresultsandwhitebloodcellindexesindiabeticretinopathy AT songyu correlationbetweenultrawidefieldfluorescencecontrastresultsandwhitebloodcellindexesindiabeticretinopathy |