Unusual presentation of extra-nodal double-hit follicular lymphoma: a case report

BACKGROUND: To the best of our knowledge, this case represents the first report of an extranodal double-hit follicular lymphoma (DH-FL) as an intestinal polypoid lesion. CASE PRESENTATION: A 72-year-old woman presents with constipation. Colonoscopy reveals a sessile polypoid lesion of the colon bear...

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Autores principales: Lazzi, Stefano, Granai, Massimo, Capanni, Marco, Fend, Falko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123749/
https://www.ncbi.nlm.nih.gov/pubmed/35596142
http://dx.doi.org/10.1186/s12876-022-02308-8
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author Lazzi, Stefano
Granai, Massimo
Capanni, Marco
Fend, Falko
author_facet Lazzi, Stefano
Granai, Massimo
Capanni, Marco
Fend, Falko
author_sort Lazzi, Stefano
collection PubMed
description BACKGROUND: To the best of our knowledge, this case represents the first report of an extranodal double-hit follicular lymphoma (DH-FL) as an intestinal polypoid lesion. CASE PRESENTATION: A 72-year-old woman presents with constipation. Colonoscopy reveals a sessile polypoid lesion of the colon bearing morphological, immunohistochemical and molecular hallmarks of DH-FL. Complete clinical staging and bone marrow biopsy showed no signs of disseminated disease. The patient, after two years of follow-up is still free of disease confirming the indolent behaviour of this limited lesion. CONCLUSIONS: A synoptic view at all the features of the patient and not merely at the molecular hallmarks of a disease are essential to establish the correct clinical approach.
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spelling pubmed-91237492022-05-22 Unusual presentation of extra-nodal double-hit follicular lymphoma: a case report Lazzi, Stefano Granai, Massimo Capanni, Marco Fend, Falko BMC Gastroenterol Case Report BACKGROUND: To the best of our knowledge, this case represents the first report of an extranodal double-hit follicular lymphoma (DH-FL) as an intestinal polypoid lesion. CASE PRESENTATION: A 72-year-old woman presents with constipation. Colonoscopy reveals a sessile polypoid lesion of the colon bearing morphological, immunohistochemical and molecular hallmarks of DH-FL. Complete clinical staging and bone marrow biopsy showed no signs of disseminated disease. The patient, after two years of follow-up is still free of disease confirming the indolent behaviour of this limited lesion. CONCLUSIONS: A synoptic view at all the features of the patient and not merely at the molecular hallmarks of a disease are essential to establish the correct clinical approach. BioMed Central 2022-05-20 /pmc/articles/PMC9123749/ /pubmed/35596142 http://dx.doi.org/10.1186/s12876-022-02308-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Lazzi, Stefano
Granai, Massimo
Capanni, Marco
Fend, Falko
Unusual presentation of extra-nodal double-hit follicular lymphoma: a case report
title Unusual presentation of extra-nodal double-hit follicular lymphoma: a case report
title_full Unusual presentation of extra-nodal double-hit follicular lymphoma: a case report
title_fullStr Unusual presentation of extra-nodal double-hit follicular lymphoma: a case report
title_full_unstemmed Unusual presentation of extra-nodal double-hit follicular lymphoma: a case report
title_short Unusual presentation of extra-nodal double-hit follicular lymphoma: a case report
title_sort unusual presentation of extra-nodal double-hit follicular lymphoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123749/
https://www.ncbi.nlm.nih.gov/pubmed/35596142
http://dx.doi.org/10.1186/s12876-022-02308-8
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