Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents

Cyclophilin A (CypA) is linked to diverse human diseases including viral infections. With the worldwide emergence of severe acute respiratory coronavirus 2 (SARS-CoV-2), drug repurposing has been highlighted as a strategy with the potential to speed up antiviral development. Because CypA acts as a p...

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Autores principales: Han, Jinhe, Lee, Myoung Kyu, Jang, Yejin, Cho, Won-Jea, Kim, Meehyein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2022
Materias:
Keynote (Green)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123807/
https://www.ncbi.nlm.nih.gov/pubmed/35609743
http://dx.doi.org/10.1016/j.drudis.2022.05.016
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author Han, Jinhe
Lee, Myoung Kyu
Jang, Yejin
Cho, Won-Jea
Kim, Meehyein
author_facet Han, Jinhe
Lee, Myoung Kyu
Jang, Yejin
Cho, Won-Jea
Kim, Meehyein
author_sort Han, Jinhe
collection PubMed
description Cyclophilin A (CypA) is linked to diverse human diseases including viral infections. With the worldwide emergence of severe acute respiratory coronavirus 2 (SARS-CoV-2), drug repurposing has been highlighted as a strategy with the potential to speed up antiviral development. Because CypA acts as a proviral component in hepatitis C virus, coronavirus and HIV, its inhibitors have been suggested as potential treatments for these infections. Here, we review the structure of cyclosporin A and sanglifehrin A analogs as well as synthetic micromolecules inhibiting CypA; and we discuss their broad-spectrum antiviral efficacy in the context of the virus lifecycle.
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spelling pubmed-91238072022-05-21 Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents Han, Jinhe Lee, Myoung Kyu Jang, Yejin Cho, Won-Jea Kim, Meehyein Drug Discov Today Keynote (Green) Cyclophilin A (CypA) is linked to diverse human diseases including viral infections. With the worldwide emergence of severe acute respiratory coronavirus 2 (SARS-CoV-2), drug repurposing has been highlighted as a strategy with the potential to speed up antiviral development. Because CypA acts as a proviral component in hepatitis C virus, coronavirus and HIV, its inhibitors have been suggested as potential treatments for these infections. Here, we review the structure of cyclosporin A and sanglifehrin A analogs as well as synthetic micromolecules inhibiting CypA; and we discuss their broad-spectrum antiviral efficacy in the context of the virus lifecycle. Published by Elsevier Ltd. 2022-07 2022-05-21 /pmc/articles/PMC9123807/ /pubmed/35609743 http://dx.doi.org/10.1016/j.drudis.2022.05.016 Text en © 2022 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Keynote (Green)
Han, Jinhe
Lee, Myoung Kyu
Jang, Yejin
Cho, Won-Jea
Kim, Meehyein
Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents
title Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents
title_full Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents
title_fullStr Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents
title_full_unstemmed Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents
title_short Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents
title_sort repurposing of cyclophilin a inhibitors as broad-spectrum antiviral agents
topic Keynote (Green)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123807/
https://www.ncbi.nlm.nih.gov/pubmed/35609743
http://dx.doi.org/10.1016/j.drudis.2022.05.016
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