Inactivation of Influenza Viruses with Heteropolyacids

The antiviral activity of Keggin heteropolyacids (HPAs) against the human influenza A/California/07/09 (H1N1) pdm09 virus is studied in MDCK cell culture. Transmission electron microscopy reveals new features of the destruction of viral particles by HPAs. A proton-anion model that considers the main...

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Autores principales: Dalidchik, F. I., Balashov, E. M., Baklanova, O. V., Gushchina, E. A., Ivashkevich, N. M., Isaeva, E. I., Kovalevskiy, S. A., Kulak, A. I., Lopatina, O. A., Fedyakina, I. T., Mezentseva, M. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2022
Materias:
Nanobiology and Genetics, Omics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123832/
http://dx.doi.org/10.1134/S2635167622020070
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author Dalidchik, F. I.
Balashov, E. M.
Baklanova, O. V.
Gushchina, E. A.
Ivashkevich, N. M.
Isaeva, E. I.
Kovalevskiy, S. A.
Kulak, A. I.
Lopatina, O. A.
Fedyakina, I. T.
Mezentseva, M. V.
author_facet Dalidchik, F. I.
Balashov, E. M.
Baklanova, O. V.
Gushchina, E. A.
Ivashkevich, N. M.
Isaeva, E. I.
Kovalevskiy, S. A.
Kulak, A. I.
Lopatina, O. A.
Fedyakina, I. T.
Mezentseva, M. V.
author_sort Dalidchik, F. I.
collection PubMed
description The antiviral activity of Keggin heteropolyacids (HPAs) against the human influenza A/California/07/09 (H1N1) pdm09 virus is studied in MDCK cell culture. Transmission electron microscopy reveals new features of the destruction of viral particles by HPAs. A proton-anion model that considers the main biochemical processes leading to the destruction of enveloped viruses: the depletion of membrane cholesterol by HPA anions, acidification of the M1 matrix protein by protons of the medium, and anion lysis of lipid membranes, is proposed. The Arrhenius dependences of the biological properties of HPAs on temperature are predicted. The general mechanism for the formation of high biological activity HPAs is described, which is underlined by the anion depletion of cholesterol in bilipid membranes, a new effect in the biochemistry of polyoxometalates.
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spelling pubmed-91238322022-05-21 Inactivation of Influenza Viruses with Heteropolyacids Dalidchik, F. I. Balashov, E. M. Baklanova, O. V. Gushchina, E. A. Ivashkevich, N. M. Isaeva, E. I. Kovalevskiy, S. A. Kulak, A. I. Lopatina, O. A. Fedyakina, I. T. Mezentseva, M. V. Nanotechnol Russia Nanobiology and Genetics, Omics The antiviral activity of Keggin heteropolyacids (HPAs) against the human influenza A/California/07/09 (H1N1) pdm09 virus is studied in MDCK cell culture. Transmission electron microscopy reveals new features of the destruction of viral particles by HPAs. A proton-anion model that considers the main biochemical processes leading to the destruction of enveloped viruses: the depletion of membrane cholesterol by HPA anions, acidification of the M1 matrix protein by protons of the medium, and anion lysis of lipid membranes, is proposed. The Arrhenius dependences of the biological properties of HPAs on temperature are predicted. The general mechanism for the formation of high biological activity HPAs is described, which is underlined by the anion depletion of cholesterol in bilipid membranes, a new effect in the biochemistry of polyoxometalates. Pleiades Publishing 2022-05-21 2022 /pmc/articles/PMC9123832/ http://dx.doi.org/10.1134/S2635167622020070 Text en © Pleiades Publishing, Ltd. 2022, ISSN 2635-1676, Nanobiotechnology Reports, 2022, Vol. 17, No. 2, pp. 193–201. © Pleiades Publishing, Ltd., 2022. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Nanobiology and Genetics, Omics
Dalidchik, F. I.
Balashov, E. M.
Baklanova, O. V.
Gushchina, E. A.
Ivashkevich, N. M.
Isaeva, E. I.
Kovalevskiy, S. A.
Kulak, A. I.
Lopatina, O. A.
Fedyakina, I. T.
Mezentseva, M. V.
Inactivation of Influenza Viruses with Heteropolyacids
title Inactivation of Influenza Viruses with Heteropolyacids
title_full Inactivation of Influenza Viruses with Heteropolyacids
title_fullStr Inactivation of Influenza Viruses with Heteropolyacids
title_full_unstemmed Inactivation of Influenza Viruses with Heteropolyacids
title_short Inactivation of Influenza Viruses with Heteropolyacids
title_sort inactivation of influenza viruses with heteropolyacids
topic Nanobiology and Genetics, Omics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123832/
http://dx.doi.org/10.1134/S2635167622020070
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