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Phonemic restoration in Alzheimer’s disease and semantic dementia: a preliminary investigation
Phonemic restoration—perceiving speech sounds that are actually missing—is a fundamental perceptual process that ‘repairs’ interrupted spoken messages during noisy everyday listening. As a dynamic, integrative process, phonemic restoration is potentially affected by neurodegenerative pathologies, bu...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123842/ https://www.ncbi.nlm.nih.gov/pubmed/35611314 http://dx.doi.org/10.1093/braincomms/fcac118 |
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author | Jiang, Jessica Johnson, Jeremy C. S. Requena-Komuro, Maï-Carmen Benhamou, Elia Sivasathiaseelan, Harri Sheppard, Damion L. Volkmer, Anna Crutch, Sebastian J. Hardy, Chris J. D. Warren, Jason D |
author_facet | Jiang, Jessica Johnson, Jeremy C. S. Requena-Komuro, Maï-Carmen Benhamou, Elia Sivasathiaseelan, Harri Sheppard, Damion L. Volkmer, Anna Crutch, Sebastian J. Hardy, Chris J. D. Warren, Jason D |
author_sort | Jiang, Jessica |
collection | PubMed |
description | Phonemic restoration—perceiving speech sounds that are actually missing—is a fundamental perceptual process that ‘repairs’ interrupted spoken messages during noisy everyday listening. As a dynamic, integrative process, phonemic restoration is potentially affected by neurodegenerative pathologies, but this has not been clarified. Here, we studied this phenomenon in 5 patients with typical Alzheimer’s disease and 4 patients with semantic dementia, relative to 22 age-matched healthy controls. Participants heard isolated sounds, spoken real words and pseudowords in which noise bursts either overlaid a consonant or replaced it; a tendency to hear replaced (missing) speech sounds as present signified phonemic restoration. All groups perceived isolated noises normally and showed phonemic restoration of real words, most marked in Alzheimer’s patients. For pseudowords, healthy controls showed no phonemic restoration, while Alzheimer’s patients showed marked suppression of phonemic restoration and patients with semantic dementia contrastingly showed phonemic restoration comparable to real words. Our findings provide the first evidence that phonemic restoration is preserved or even enhanced in neurodegenerative diseases, with distinct syndromic profiles that may reflect the relative integrity of bottom-up phonological representation and top-down lexical disambiguation mechanisms in different diseases. This work has theoretical implications for predictive coding models of language and neurodegenerative disease and for understanding cognitive ‘repair’ processes in dementia. Future research should expand on these preliminary observations with larger cohorts. |
format | Online Article Text |
id | pubmed-9123842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-91238422022-05-23 Phonemic restoration in Alzheimer’s disease and semantic dementia: a preliminary investigation Jiang, Jessica Johnson, Jeremy C. S. Requena-Komuro, Maï-Carmen Benhamou, Elia Sivasathiaseelan, Harri Sheppard, Damion L. Volkmer, Anna Crutch, Sebastian J. Hardy, Chris J. D. Warren, Jason D Brain Commun Original Article Phonemic restoration—perceiving speech sounds that are actually missing—is a fundamental perceptual process that ‘repairs’ interrupted spoken messages during noisy everyday listening. As a dynamic, integrative process, phonemic restoration is potentially affected by neurodegenerative pathologies, but this has not been clarified. Here, we studied this phenomenon in 5 patients with typical Alzheimer’s disease and 4 patients with semantic dementia, relative to 22 age-matched healthy controls. Participants heard isolated sounds, spoken real words and pseudowords in which noise bursts either overlaid a consonant or replaced it; a tendency to hear replaced (missing) speech sounds as present signified phonemic restoration. All groups perceived isolated noises normally and showed phonemic restoration of real words, most marked in Alzheimer’s patients. For pseudowords, healthy controls showed no phonemic restoration, while Alzheimer’s patients showed marked suppression of phonemic restoration and patients with semantic dementia contrastingly showed phonemic restoration comparable to real words. Our findings provide the first evidence that phonemic restoration is preserved or even enhanced in neurodegenerative diseases, with distinct syndromic profiles that may reflect the relative integrity of bottom-up phonological representation and top-down lexical disambiguation mechanisms in different diseases. This work has theoretical implications for predictive coding models of language and neurodegenerative disease and for understanding cognitive ‘repair’ processes in dementia. Future research should expand on these preliminary observations with larger cohorts. Oxford University Press 2022-05-07 /pmc/articles/PMC9123842/ /pubmed/35611314 http://dx.doi.org/10.1093/braincomms/fcac118 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jiang, Jessica Johnson, Jeremy C. S. Requena-Komuro, Maï-Carmen Benhamou, Elia Sivasathiaseelan, Harri Sheppard, Damion L. Volkmer, Anna Crutch, Sebastian J. Hardy, Chris J. D. Warren, Jason D Phonemic restoration in Alzheimer’s disease and semantic dementia: a preliminary investigation |
title | Phonemic restoration in Alzheimer’s disease and semantic dementia: a preliminary investigation |
title_full | Phonemic restoration in Alzheimer’s disease and semantic dementia: a preliminary investigation |
title_fullStr | Phonemic restoration in Alzheimer’s disease and semantic dementia: a preliminary investigation |
title_full_unstemmed | Phonemic restoration in Alzheimer’s disease and semantic dementia: a preliminary investigation |
title_short | Phonemic restoration in Alzheimer’s disease and semantic dementia: a preliminary investigation |
title_sort | phonemic restoration in alzheimer’s disease and semantic dementia: a preliminary investigation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123842/ https://www.ncbi.nlm.nih.gov/pubmed/35611314 http://dx.doi.org/10.1093/braincomms/fcac118 |
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