Cargando…

Exploration of 4-aminopyrrolo[2,3-d]pyrimidine as antitubercular agents

Tuberculosis (TB) is one of the leading causes of death worldwide. Developing new anti-TB compounds using cost-effective processes is critical to reduce TB incidence and accomplish the End TB Strategy milestone. Herein, we describe the synthesis and structure–activity relationships of a library of t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jesumoroti, Omobolanle Janet, Beteck, Richard M., Jordaan, Audrey, Warner, Digby F., Legoabe, Lesetja J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124159/ https://www.ncbi.nlm.nih.gov/pubmed/35598185 http://dx.doi.org/10.1007/s11030-022-10453-1

Ejemplares similares

Quinolone-3-amidoalkanol: A New Class of Potent and Broad-Spectrum Antimicrobial Agent
por: Dube, Phelelisiwe S., et al.
Publicado: (2023)

Chemical Classes Presenting Novel Antituberculosis Agents Currently in Different Phases of Drug Development: A 2010–2020 Review
por: Angula, Klaudia T., et al.
Publicado: (2021)

Quinolone: a versatile therapeutic compound class
por: Dube, Phelelisiwe S., et al.
Publicado: (2022)

An Update on Development of Small-Molecule Plasmodial Kinase Inhibitors
por: Moolman, Chantalle, et al.
Publicado: (2020)

New Quinoline–Urea–Benzothiazole Hybrids as Promising Antitubercular Agents: Synthesis, In Vitro Antitubercular Activity, Cytotoxicity Studies, and In Silico ADME Profiling
por: Moodley, Rashmika, et al.
Publicado: (2022)

Exploration of Piperidinols as Potential Antitubercular Agents
por: Abuhammad, Areej, et al.
Publicado: (2014)

Anti-Trypanosomal and Antimalarial Properties of Tetralone Derivatives and Structurally Related Benzocycloalkanones
por: Beteck, Richard M., et al.
Publicado: (2019)

New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum and Mycobacterium tuberculosis
por: Beteck, Richard M., et al.
Publicado: (2019)

Easy-To-Access Quinolone Derivatives Exhibiting Antibacterial and Anti-Parasitic Activities
por: Beteck, Richard M., et al.
Publicado: (2021)

Structure–Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents
por: Oh, Sangmi, et al.
Publicado: (2021)

Design, synthesis and evaluation of amino-3,5-dicyanopyridines and thieno[2,3-b]pyridines as ligands of adenosine A(1) receptors for the potential treatment of epilepsy
por: Nkomba, Gaofenngwe, et al.
Publicado: (2022)

Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agents
por: Kumar, Adarsh, et al.
Publicado: (2023)

2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors
por: Legoabe, Lesetja J, et al.
Publicado: (2015)

New Conjugates of Quinoxaline as Potent Antitubercular and Antibacterial Agents
por: Peraman, Ramalingam, et al.
Publicado: (2016)

3-Coumaranone derivatives as inhibitors of monoamine oxidase
por: Van Dyk, Adriaan S, et al.
Publicado: (2015)

C3 amino-substituted chalcone derivative with selective adenosine rA(1) receptor affinity in the micromolar range
por: Janse van Rensburg, Helena D., et al.
Publicado: (2020)

Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents
por: Abdelhameed, Reda M., et al.
Publicado: (2020)

Phytogenic silver, gold, and bimetallic nanoparticles as novel antitubercular agents
por: Singh, Richa, et al.
Publicado: (2016)

Rational design and synthesis of novel diphenyl ether derivatives as antitubercular agents
por: Kar, Sidhartha S, et al.
Publicado: (2016)

Nigella sativa L. and Its Active Compound Thymoquinone in the Clinical Management of Diabetes: A Systematic Review
por: Mahomoodally, Mohamad Fawzi, et al.
Publicado: (2022)

Synthesis, Biological Evaluation and 2D-QSAR Study of Halophenyl Bis-Hydrazones as Antimicrobial and Antitubercular Agents
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2015)

New Routes to Pyridino[2,3-d]pyrimidin-4-one and Pyridino-[2,3-d]triazolino[4,5-a]pyrimidin-5-one Derivatives
por: Hassneen, Hamdi M., et al.
Publicado: (2003)

Plants’ bioactive secondary metabolites in the management of sepsis: Recent findings on their mechanism of action
por: Mahomoodally, Mohamad Fawzi, et al.
Publicado: (2022)

4-Chloro-1H-pyrrolo[2,3-d]pyrimidine
por: Dong, Su-Lan, et al.
Publicado: (2012)

Synthesis, In Vitro Screening and Docking Studies of New Thiosemicarbazide Derivatives as Antitubercular Agents
por: Pitucha, Monika, et al.
Publicado: (2019)

Cinnamic Derivatives as Antitubercular Agents: Characterization by Quantitative Structure–Activity Relationship Studies
por: Teixeira, Cátia, et al.
Publicado: (2020)

Papulonecrotic tuberculid caused by Bacille Calmette-Guerin vaccination requiring no antitubercular agents
por: Araki, Kotaro, et al.
Publicado: (2020)

Comparison of the Efficacy of Two Novel Antitubercular Agents in Free and Liposome-Encapsulated Formulations
por: Kósa, Nikoletta, et al.
Publicado: (2021)

Synthesis, Antibacterial and Antitubercular Activities of Some 5H-Thiazolo[3,2-a]pyrimidin-5-ones and Sulfonic Acid Derivatives
por: Cai, Dong, et al.
Publicado: (2015)

Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones
por: Polaquini, Carlos R., et al.
Publicado: (2017)

Pharmacovigilance of Antitubercular Therapy in Tuberculosis
por: Ravichandran, Mirunalini, et al.
Publicado: (2022)

Antituberculars: Hepatitis: case report
Publicado: (2022)

Design, Synthesis, and Biological Activity of Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine Derivatives as Anti-Inflammatory Agents
por: Zhang, Yuan, et al.
Publicado: (2017)

4,7-Disubstituted 7H-Pyrrolo[2,3-d]pyrimidines and Their Analogs as Antiviral Agents against Zika Virus
por: Soto-Acosta, Ruben, et al.
Publicado: (2021)

The evaluation of 1-tetralone and 4-chromanone derivatives as inhibitors of monoamine oxidase
por: Cloete, Stephanus J., et al.
Publicado: (2020)

Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives as novel EGFR(L858R/T790M) inhibitors
por: Fu, Jianfang, et al.
Publicado: (2023)

Hepatoprotective Evaluation of Trapa natans against Drug-induced Hepatotoxicity of Antitubercular Agents in Rats
por: Hussain, Talib, et al.
Publicado: (2018)

Dataset of 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole derivatives for GQSAR of antitubercular agents
por: Tapkir, Amit S., et al.
Publicado: (2017)

Synthesis, Characterization, and Biological Evaluation of New Derivatives Targeting MbtI as Antitubercular Agents
por: Mori, Matteo, et al.
Publicado: (2021)

Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility
por: Ang, Chee Wei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s1srd6aloi2vd4tuo7vu2r179k