Bone response in vivo of Ti-45Zr alloy as dental implant material

Ti-Zr alloys have gained increasing attention as a new metallic biomaterial, being used as implants for both orthopedics and dentistry. More recently, our group found promising results for the Ti-45Zr alloy, which presented a low elastic modulus, a pronounced and excellent mechanic character, and ex...

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Autores principales: Ou, Pinghua, Zhang, Taomei, Wang, Jianying, Li, Cui, Shao, Chunsheng, Ruan, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Biocompatibility Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124165/
https://www.ncbi.nlm.nih.gov/pubmed/35596895
http://dx.doi.org/10.1007/s10856-022-06664-5
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author Ou, Pinghua
Zhang, Taomei
Wang, Jianying
Li, Cui
Shao, Chunsheng
Ruan, Jianming
author_facet Ou, Pinghua
Zhang, Taomei
Wang, Jianying
Li, Cui
Shao, Chunsheng
Ruan, Jianming
author_sort Ou, Pinghua
collection PubMed
description Ti-Zr alloys have gained increasing attention as a new metallic biomaterial, being used as implants for both orthopedics and dentistry. More recently, our group found promising results for the Ti-45Zr alloy, which presented a low elastic modulus, a pronounced and excellent mechanic character, and excellent cell compatibility in vitro. However, its biocompatibility and potential to promote osteogenesis in vivo remained unclear. In the present study, the biocompatibility, osteointegration ability, and immune response effects of the Ti-45Zr alloy were evaluated in animal experiments. The results showed that the alloy had good blood compatibility and no body side effects. After implantation in vivo, the inflammation turned out well and was beneficial to the polarization of macrophages. Additionally, the Ti-45Zr alloy presented a good osteointegration ability. Overall, these results confirmed that the Ti-45Zr alloy can be used as a dental implant material.
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spelling pubmed-91241652022-05-23 Bone response in vivo of Ti-45Zr alloy as dental implant material Ou, Pinghua Zhang, Taomei Wang, Jianying Li, Cui Shao, Chunsheng Ruan, Jianming J Mater Sci Mater Med Biocompatibility Studies Ti-Zr alloys have gained increasing attention as a new metallic biomaterial, being used as implants for both orthopedics and dentistry. More recently, our group found promising results for the Ti-45Zr alloy, which presented a low elastic modulus, a pronounced and excellent mechanic character, and excellent cell compatibility in vitro. However, its biocompatibility and potential to promote osteogenesis in vivo remained unclear. In the present study, the biocompatibility, osteointegration ability, and immune response effects of the Ti-45Zr alloy were evaluated in animal experiments. The results showed that the alloy had good blood compatibility and no body side effects. After implantation in vivo, the inflammation turned out well and was beneficial to the polarization of macrophages. Additionally, the Ti-45Zr alloy presented a good osteointegration ability. Overall, these results confirmed that the Ti-45Zr alloy can be used as a dental implant material. Springer US 2022-05-21 2022 /pmc/articles/PMC9124165/ /pubmed/35596895 http://dx.doi.org/10.1007/s10856-022-06664-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biocompatibility Studies
Ou, Pinghua
Zhang, Taomei
Wang, Jianying
Li, Cui
Shao, Chunsheng
Ruan, Jianming
Bone response in vivo of Ti-45Zr alloy as dental implant material
title Bone response in vivo of Ti-45Zr alloy as dental implant material
title_full Bone response in vivo of Ti-45Zr alloy as dental implant material
title_fullStr Bone response in vivo of Ti-45Zr alloy as dental implant material
title_full_unstemmed Bone response in vivo of Ti-45Zr alloy as dental implant material
title_short Bone response in vivo of Ti-45Zr alloy as dental implant material
title_sort bone response in vivo of ti-45zr alloy as dental implant material
topic Biocompatibility Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124165/
https://www.ncbi.nlm.nih.gov/pubmed/35596895
http://dx.doi.org/10.1007/s10856-022-06664-5
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