Cargando…
A longitudinal study of the impact of university student return to campus on the SARS-CoV-2 seroprevalence among the community members
Returning university students represent large-scale, transient demographic shifts and a potential source of transmission to adjacent communities during the COVID-19 pandemic. In this prospective longitudinal cohort study, we tested for IgG antibodies against SARS-CoV-2 in a non-random cohort of resi...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124192/ https://www.ncbi.nlm.nih.gov/pubmed/35597780 http://dx.doi.org/10.1038/s41598-022-12499-5 |
_version_ | 1784711693224378368 |
---|---|
author | Arnold, Callum R. K. Srinivasan, Sreenidhi Rodriguez, Sophie Rydzak, Natalie Herzog, Catherine M. Gontu, Abhinay Bharti, Nita Small, Meg Rogers, Connie J. Schade, Margeaux M. Kuchipudi, Suresh V. Kapur, Vivek Read, Andrew F. Ferrari, Matthew J. |
author_facet | Arnold, Callum R. K. Srinivasan, Sreenidhi Rodriguez, Sophie Rydzak, Natalie Herzog, Catherine M. Gontu, Abhinay Bharti, Nita Small, Meg Rogers, Connie J. Schade, Margeaux M. Kuchipudi, Suresh V. Kapur, Vivek Read, Andrew F. Ferrari, Matthew J. |
author_sort | Arnold, Callum R. K. |
collection | PubMed |
description | Returning university students represent large-scale, transient demographic shifts and a potential source of transmission to adjacent communities during the COVID-19 pandemic. In this prospective longitudinal cohort study, we tested for IgG antibodies against SARS-CoV-2 in a non-random cohort of residents living in Centre County prior to the Fall 2020 term at the Pennsylvania State University and following the conclusion of the Fall 2020 term. We also report the seroprevalence in a non-random cohort of students collected at the end of the Fall 2020 term. Of 1313 community participants, 42 (3.2%) were positive for SARS-CoV-2 IgG antibodies at their first visit between 07 August and 02 October 2020. Of 684 student participants who returned to campus for fall instruction, 208 (30.4%) were positive for SARS-CoV-2 antibodies between 26 October and 21 December. 96 (7.3%) community participants returned a positive IgG antibody result by 19 February. Only contact with known SARS-CoV-2-positive individuals and attendance at small gatherings (20–50 individuals) were significant predictors of detecting IgG antibodies among returning students (aOR, 95% CI 3.1, 2.07–4.64; 1.52, 1.03–2.24; respectively). Despite high seroprevalence observed within the student population, seroprevalence in a longitudinal cohort of community residents was low and stable from before student arrival for the Fall 2020 term to after student departure. The study implies that heterogeneity in SARS-CoV-2 transmission can occur in geographically coincident populations. |
format | Online Article Text |
id | pubmed-9124192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91241922022-05-23 A longitudinal study of the impact of university student return to campus on the SARS-CoV-2 seroprevalence among the community members Arnold, Callum R. K. Srinivasan, Sreenidhi Rodriguez, Sophie Rydzak, Natalie Herzog, Catherine M. Gontu, Abhinay Bharti, Nita Small, Meg Rogers, Connie J. Schade, Margeaux M. Kuchipudi, Suresh V. Kapur, Vivek Read, Andrew F. Ferrari, Matthew J. Sci Rep Article Returning university students represent large-scale, transient demographic shifts and a potential source of transmission to adjacent communities during the COVID-19 pandemic. In this prospective longitudinal cohort study, we tested for IgG antibodies against SARS-CoV-2 in a non-random cohort of residents living in Centre County prior to the Fall 2020 term at the Pennsylvania State University and following the conclusion of the Fall 2020 term. We also report the seroprevalence in a non-random cohort of students collected at the end of the Fall 2020 term. Of 1313 community participants, 42 (3.2%) were positive for SARS-CoV-2 IgG antibodies at their first visit between 07 August and 02 October 2020. Of 684 student participants who returned to campus for fall instruction, 208 (30.4%) were positive for SARS-CoV-2 antibodies between 26 October and 21 December. 96 (7.3%) community participants returned a positive IgG antibody result by 19 February. Only contact with known SARS-CoV-2-positive individuals and attendance at small gatherings (20–50 individuals) were significant predictors of detecting IgG antibodies among returning students (aOR, 95% CI 3.1, 2.07–4.64; 1.52, 1.03–2.24; respectively). Despite high seroprevalence observed within the student population, seroprevalence in a longitudinal cohort of community residents was low and stable from before student arrival for the Fall 2020 term to after student departure. The study implies that heterogeneity in SARS-CoV-2 transmission can occur in geographically coincident populations. Nature Publishing Group UK 2022-05-21 /pmc/articles/PMC9124192/ /pubmed/35597780 http://dx.doi.org/10.1038/s41598-022-12499-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Arnold, Callum R. K. Srinivasan, Sreenidhi Rodriguez, Sophie Rydzak, Natalie Herzog, Catherine M. Gontu, Abhinay Bharti, Nita Small, Meg Rogers, Connie J. Schade, Margeaux M. Kuchipudi, Suresh V. Kapur, Vivek Read, Andrew F. Ferrari, Matthew J. A longitudinal study of the impact of university student return to campus on the SARS-CoV-2 seroprevalence among the community members |
title | A longitudinal study of the impact of university student return to campus on the SARS-CoV-2 seroprevalence among the community members |
title_full | A longitudinal study of the impact of university student return to campus on the SARS-CoV-2 seroprevalence among the community members |
title_fullStr | A longitudinal study of the impact of university student return to campus on the SARS-CoV-2 seroprevalence among the community members |
title_full_unstemmed | A longitudinal study of the impact of university student return to campus on the SARS-CoV-2 seroprevalence among the community members |
title_short | A longitudinal study of the impact of university student return to campus on the SARS-CoV-2 seroprevalence among the community members |
title_sort | longitudinal study of the impact of university student return to campus on the sars-cov-2 seroprevalence among the community members |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124192/ https://www.ncbi.nlm.nih.gov/pubmed/35597780 http://dx.doi.org/10.1038/s41598-022-12499-5 |
work_keys_str_mv | AT arnoldcallumrk alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT srinivasansreenidhi alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT rodriguezsophie alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT rydzaknatalie alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT herzogcatherinem alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT gontuabhinay alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT bhartinita alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT smallmeg alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT rogersconniej alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT schademargeauxm alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT kuchipudisureshv alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT kapurvivek alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT readandrewf alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT ferrarimatthewj alongitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT arnoldcallumrk longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT srinivasansreenidhi longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT rodriguezsophie longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT rydzaknatalie longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT herzogcatherinem longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT gontuabhinay longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT bhartinita longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT smallmeg longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT rogersconniej longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT schademargeauxm longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT kuchipudisureshv longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT kapurvivek longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT readandrewf longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers AT ferrarimatthewj longitudinalstudyoftheimpactofuniversitystudentreturntocampusonthesarscov2seroprevalenceamongthecommunitymembers |