Dedifferentiation-mediated stem cell niche maintenance in early-stage ductal carcinoma in situ progression: insights from a multiscale modeling study

We present a multiscale agent-based model of ductal carcinoma in situ (DCIS) to study how key phenotypic and signaling pathways are involved in the early stages of disease progression. The model includes a phenotypic hierarchy, and key endocrine and paracrine signaling pathways, and simulates cancer...

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Detalles Bibliográficos
Autores principales: Butner, Joseph D., Dogra, Prashant, Chung, Caroline, Ruiz-Ramírez, Javier, Nizzero, Sara, Plodinec, Marija, Li, Xiaoxian, Pan, Ping-Ying, Chen, Shu-hsia, Cristini, Vittorio, Ozpolat, Bulent, Calin, George A., Wang, Zhihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124196/
https://www.ncbi.nlm.nih.gov/pubmed/35597788
http://dx.doi.org/10.1038/s41419-022-04939-x

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