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A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease
Synaptic dysfunction is a key feature of Alzheimer's disease (AD). However, the molecular mechanisms underlying synaptic dysfunction remain unclear. Here, we show that synapsin Ⅰ, one of the most important synaptic proteins, is fragmented by the cysteine proteinase asparagine endopeptidase (AEP...
Autores principales: | Meng, Lanxia, Zou, Li, Xiong, Min, Chen, Jiehui, Zhang, Xingyu, Yu, Ting, Li, Yiming, Liu, Congcong, Chen, Guiqin, Wang, Zhihao, Ye, Keqiang, Zhang, Zhentao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124304/ https://www.ncbi.nlm.nih.gov/pubmed/35443102 http://dx.doi.org/10.1111/acel.13619 |
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