A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease

Synaptic dysfunction is a key feature of Alzheimer's disease (AD). However, the molecular mechanisms underlying synaptic dysfunction remain unclear. Here, we show that synapsin Ⅰ, one of the most important synaptic proteins, is fragmented by the cysteine proteinase asparagine endopeptidase (AEP...

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Detalles Bibliográficos
Autores principales: Meng, Lanxia, Zou, Li, Xiong, Min, Chen, Jiehui, Zhang, Xingyu, Yu, Ting, Li, Yiming, Liu, Congcong, Chen, Guiqin, Wang, Zhihao, Ye, Keqiang, Zhang, Zhentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124304/
https://www.ncbi.nlm.nih.gov/pubmed/35443102
http://dx.doi.org/10.1111/acel.13619

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