Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity

Cellular senescence, which is a major cause of tissue dysfunction with aging and multiple other conditions, is known to be triggered by p16(Ink4a) or p21(Cip1), but the relative contributions of each pathway toward inducing senescence are unclear. Here, we directly addressed this issue by first deve...

Descripción completa

Detalles Bibliográficos
Autores principales: Chandra, Abhishek, Lagnado, Anthony B., Farr, Joshua N., Doolittle, Madison, Tchkonia, Tamara, Kirkland, James L., LeBrasseur, Nathan K., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Passos, João F., Monroe, David G., Pignolo, Robert J., Khosla, Sundeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124310/
https://www.ncbi.nlm.nih.gov/pubmed/35363946
http://dx.doi.org/10.1111/acel.13602

Ejemplares similares

Ejemplares similares