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Contribution of proteases to the hallmarks of aging and to age‐related neurodegeneration

Protein quality control ensures the degradation of damaged and misfolded proteins. Derangement of proteostasis is a primary cause of aging and age‐associated diseases. The ubiquitin–proteasome and autophagy‐lysosome play key roles in proteostasis but, in addition to these systems, the human genome e...

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Detalles Bibliográficos
Autores principales: Rai, Mamta, Curley, Michelle, Coleman, Zane, Demontis, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124314/
https://www.ncbi.nlm.nih.gov/pubmed/35349763
http://dx.doi.org/10.1111/acel.13603