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A semimechanistic population pharmacokinetic and pharmacodynamic model incorporating autoinduction for the dose justification of TAS‐114

TAS‐114 is a dual deoxyuridine triphosphatase (dUTPase) and dihydropyrimidine dehydrogenase (DPD) inhibitor expected to widen the therapeutic index of capecitabine. Its maximum tolerated dose (MTD) was determined from a safety perspective in a combination study with capecitabine; however, its inhibi...

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Detalles Bibliográficos
Autores principales:	Araki, Hikari, Takenaka, Toru, Takahashi, Koichi, Yamashita, Fumiaki, Matsuoka, Kazuaki, Yoshisue, Kunihiro, Ieiri, Ichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124359/ https://www.ncbi.nlm.nih.gov/pubmed/34951129 http://dx.doi.org/10.1002/psp4.12747

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