Cargando…
A novel cardiovascular systems model to quantify drugs effects on the inter‐relationship between contractility and other hemodynamic variables
The use of systems‐based pharmacological modeling approaches to characterize mode‐of‐action and concentration‐effect relationships for drugs on specific hemodynamic variables has been demonstrated. Here, we (i) expand a previously developed hemodynamic system model through integration of cardiac out...
Autores principales: | Fu, Yu, Taghvafard, Hadi, Said, Medhat M., Rossman, Eric I., Collins, Teresa A., Billiald‐Desquand, Stéphanie, Leishman, Derek, van der Graaf, Piet H., van Hasselt, J. G. Coen, Snelder, Nelleke |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124360/ https://www.ncbi.nlm.nih.gov/pubmed/35213797 http://dx.doi.org/10.1002/psp4.12774 |
Ejemplares similares
-
Evaluation of a Cardiovascular Systems Model for Design and Analysis of Hemodynamic Safety Studies
por: Fu, Yu, et al.
Publicado: (2023) -
Predictions of Bedaquiline and Pretomanid Target Attainment in Lung Lesions of Tuberculosis Patients using Translational Minimal Physiologically Based Pharmacokinetic Modeling
por: Mehta, Krina, et al.
Publicado: (2023) -
Characterisation of the pharmacokinetics of ethinylestradiol and drospirenone in extended-cycle regimens: population pharmacokinetic analysis from a randomised Phase III study
por: Reif, Stefanie, et al.
Publicado: (2013) -
Design principles of collateral sensitivity-based dosing strategies
por: Aulin, Linda B. S., et al.
Publicado: (2021) -
Impact of mitochondrial nitrite reductase on hemodynamics and myocardial contractility
por: Dungel, Peter, et al.
Publicado: (2017)