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APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types

BACKGROUND: The APOBEC3 (apolipoprotein B mRNA editing enzyme catalytic polypeptide 3) family of cytidine deaminases is responsible for two mutational signatures (SBS2 and SBS13) found in cancer genomes. APOBEC3 enzymes are activated in response to viral infection, and have been associated with incr...

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Detalles Bibliográficos
Autores principales:	Jakobsdottir, G. Maria, Brewer, Daniel S, Cooper, Colin, Green, Catherine, Wedge, David C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124393/ https://www.ncbi.nlm.nih.gov/pubmed/35597990 http://dx.doi.org/10.1186/s12915-022-01316-0

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