Can metformin relieve tibiofemoral cartilage volume loss and knee symptoms in overweight knee osteoarthritis patients? Study protocol for a randomized, double-blind, and placebo-controlled trial

BACKGROUND: Osteoarthritis (OA) is the most common joint disease, and is most frequently seen in the knees. However, there is no effective therapy to relieve the progression of knee OA. Metformin is a safe, well-tolerated oral medication that is extensively used as first-line therapy for type 2 diab...

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Detalles Bibliográficos
Autores principales: Ruan, Guangfeng, Yuan, Shiwen, Lou, Aiju, Mo, Yingqian, Qu, Yuan, Guo, Dongmei, Guan, Shangqi, Zhang, Yan, Lan, Xiaoyong, Luo, Jun, Mei, Yifang, Zhang, Hongwei, Wu, Weirong, Dai, Lie, Yu, Qinghong, Cai, Xiaoyan, Ding, Changhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124394/
https://www.ncbi.nlm.nih.gov/pubmed/35598008
http://dx.doi.org/10.1186/s12891-022-05434-2

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