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A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinson’s disease

BACKGROUND: The α-synuclein released by neurons activates microglia, which then engulfs α-synuclein for degradation via autophagy. Reactive microglia are a major pathological feature of Parkinson’s disease (PD), although the exact role of microglia in the pathogenesis of PD remains unclear. Transien...

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Detalles Bibliográficos
Autores principales:	Lu, Jia, Wang, Chenfei, Cheng, Xin, Wang, Ruizhi, Yan, Xuehan, He, Pengju, Chen, Hongzhuan, Yu, Zhihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124408/ https://www.ncbi.nlm.nih.gov/pubmed/35599331 http://dx.doi.org/10.1186/s12974-022-02484-0

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