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Multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review

BACKGROUND: Prostate cancer (PC) is mainly known to metastasize to bone, lung and liver, but isolated metastases of prostate cancer, including ductal carcinoma, in the urinary tract are very rare. We describe two patients with nodular masses in the urinary tract (the anterior urethra or the urinary...

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Autores principales: Masuda, Tsukasa, Kosaka, Takeo, Nakamura, Kohei, Hongo, Hiroshi, Yuge, Kazuyuki, Nishihara, Hiroshi, Oya, Mototsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124419/
https://www.ncbi.nlm.nih.gov/pubmed/35598018
http://dx.doi.org/10.1186/s12920-022-01267-z
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author Masuda, Tsukasa
Kosaka, Takeo
Nakamura, Kohei
Hongo, Hiroshi
Yuge, Kazuyuki
Nishihara, Hiroshi
Oya, Mototsugu
author_facet Masuda, Tsukasa
Kosaka, Takeo
Nakamura, Kohei
Hongo, Hiroshi
Yuge, Kazuyuki
Nishihara, Hiroshi
Oya, Mototsugu
author_sort Masuda, Tsukasa
collection PubMed
description BACKGROUND: Prostate cancer (PC) is mainly known to metastasize to bone, lung and liver, but isolated metastases of prostate cancer, including ductal carcinoma, in the urinary tract are very rare. We describe two patients with nodular masses in the urinary tract (the anterior urethra or the urinary bladder) that were found on cystoscopy during treatment of castration-resistant prostate cancer. CASE PRESENTATION: In both cases, the pathological diagnosis from transurethral tumor resection showed that they were androgen indifferent prostate cancer (AIPC), including aggressive variant prostate cancer (AVPC) in Case 1 and treatment-induced neuroendocrine differentiation prostate cancer (NEPC) in Case 2. In Case 1, Loss of genetic heterozygosity (LOH) of BRCA2 and gene amplification of KRAS was identified from the urethra polyps. In Case 2, homozygous deletion was observed in PTEN, and LOH without mutation was observed in RB1. CONCLUSION: These are the first reports of two cases of urinary tract metastasis of AIPC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-022-01267-z.
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spelling pubmed-91244192022-05-23 Multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review Masuda, Tsukasa Kosaka, Takeo Nakamura, Kohei Hongo, Hiroshi Yuge, Kazuyuki Nishihara, Hiroshi Oya, Mototsugu BMC Med Genomics Case Report BACKGROUND: Prostate cancer (PC) is mainly known to metastasize to bone, lung and liver, but isolated metastases of prostate cancer, including ductal carcinoma, in the urinary tract are very rare. We describe two patients with nodular masses in the urinary tract (the anterior urethra or the urinary bladder) that were found on cystoscopy during treatment of castration-resistant prostate cancer. CASE PRESENTATION: In both cases, the pathological diagnosis from transurethral tumor resection showed that they were androgen indifferent prostate cancer (AIPC), including aggressive variant prostate cancer (AVPC) in Case 1 and treatment-induced neuroendocrine differentiation prostate cancer (NEPC) in Case 2. In Case 1, Loss of genetic heterozygosity (LOH) of BRCA2 and gene amplification of KRAS was identified from the urethra polyps. In Case 2, homozygous deletion was observed in PTEN, and LOH without mutation was observed in RB1. CONCLUSION: These are the first reports of two cases of urinary tract metastasis of AIPC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-022-01267-z. BioMed Central 2022-05-21 /pmc/articles/PMC9124419/ /pubmed/35598018 http://dx.doi.org/10.1186/s12920-022-01267-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Masuda, Tsukasa
Kosaka, Takeo
Nakamura, Kohei
Hongo, Hiroshi
Yuge, Kazuyuki
Nishihara, Hiroshi
Oya, Mototsugu
Multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review
title Multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review
title_full Multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review
title_fullStr Multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review
title_full_unstemmed Multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review
title_short Multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review
title_sort multiple metastases of androgen indifferent prostate cancer in the urinary tract: two case reports and a literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124419/
https://www.ncbi.nlm.nih.gov/pubmed/35598018
http://dx.doi.org/10.1186/s12920-022-01267-z
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