C3aR costimulation enhances the antitumor efficacy of CAR-T cell therapy through Th17 expansion and memory T cell induction

Although chimeric antigen receptor (CAR)-modified adoptive T cell therapy is a promising immunotherapy for hematological malignancies, the efficacy improvement in relapsed/refractory acute lymphoblastic leukemia (ALL) with extramedullary infiltration and in multiple myeloma (MM) is still warranted....

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Detalles Bibliográficos
Autores principales: Lai, Peilong, Chen, Xiaomei, Wang, Yulian, Wang, Jinghua, Zhang, Yuchen, Geng, Suxia, Li, Peng, Du, Xin, Weng, Jianyu, Pei, Duanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124432/
https://www.ncbi.nlm.nih.gov/pubmed/35597971
http://dx.doi.org/10.1186/s13045-022-01288-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124432/
https://www.ncbi.nlm.nih.gov/pubmed/35597971
http://dx.doi.org/10.1186/s13045-022-01288-2

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